Prenatal stress affects viability, activation, and chemokine signaling in astroglial cultures.
J Neuroimmunol
; 311: 79-87, 2017 10 15.
Article
en En
| MEDLINE
| ID: mdl-28844502
ABSTRACT
CXCL12/SDF-1α and CX3CL1/fractalkine are constitutively expressed in the brain, which indicates their significant functions. Emerging evidence highlights the role of astrocytes and the immune system in the pathophysiology of stress-related disorders. The aim of this study was to assess whether prenatal stress affects chemokine signaling, cell viability/activation, and the iNOS pathway in astroglial cultures. Our results showed that prenatal stress lowered astrocyte viability and simultaneously increased GFAP expression. Furthermore, CX3CL1 production and the CXCL12/CXCR4-7 axis were also altered by prenatal stress. Taken together, malfunctions caused by prenatal stress may adversely influence brain development, leading to long-term effects on adult brain function and behavior.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Efectos Tardíos de la Exposición Prenatal
/
Estrés Psicológico
/
Transducción de Señal
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Astrocitos
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Quimiocinas
Límite:
Animals
/
Pregnancy
Idioma:
En
Revista:
J Neuroimmunol
Año:
2017
Tipo del documento:
Article
País de afiliación:
Polonia