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Phenotypic Optimization of Urea-Thiophene Carboxamides To Yield Potent, Well Tolerated, and Orally Active Protective Agents against Aminoglycoside-Induced Hearing Loss.
Chowdhury, Sarwat; Owens, Kelly N; Herr, R Jason; Jiang, Qin; Chen, Xinchao; Johnson, Graham; Groppi, Vincent E; Raible, David W; Rubel, Edwin W; Simon, Julian A.
Afiliación
  • Owens KN; Virginia Merrill Bloedel Hearing Research Center, University of Washington , Seattle, Washington 98195, United States.
  • Herr RJ; AMRI , Albany, New York 12203, United States.
  • Jiang Q; AMRI , Albany, New York 12203, United States.
  • Chen X; AMRI , Albany, New York 12203, United States.
  • Johnson G; NuPharmAdvise LLC , Sanbornton, New Hampshire 03269 United States.
  • Groppi VE; Oricula Therapeutics , Seattle, Washington 98154, United States.
  • Raible DW; Center for Discovery of New Molecules, University of Michigan , Ann Arbor, Michigan 48109, United States.
  • Rubel EW; Virginia Merrill Bloedel Hearing Research Center, University of Washington , Seattle, Washington 98195, United States.
  • Simon JA; Department of Biological Structure, University of Washington , Seattle, Washington 98195, United States.
J Med Chem ; 61(1): 84-97, 2018 01 11.
Article en En | MEDLINE | ID: mdl-28992413
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Texto completo: 1 Colección: 01-internacional Asunto principal: Seguridad / Tiofenos / Urea / Aminoglicósidos / Pérdida Auditiva Límite: Animals Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2018 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Asunto principal: Seguridad / Tiofenos / Urea / Aminoglicósidos / Pérdida Auditiva Límite: Animals Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2018 Tipo del documento: Article