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Asialoglycoprotein receptor 1 mediates productive uptake of N-acetylgalactosamine-conjugated and unconjugated phosphorothioate antisense oligonucleotides into liver hepatocytes.
Tanowitz, Michael; Hettrick, Lisa; Revenko, Alexey; Kinberger, Garth A; Prakash, Thazha P; Seth, Punit P.
Afiliación
  • Tanowitz M; Department of Medicinal Chemistry, Ionis Pharmaceuticals, Inc. 2855 Gazelle Court, Carlsbad, CA 92010, USA.
  • Hettrick L; Department of Antisense Drug Discovery, Ionis Pharmaceuticals, Inc. 2855 Gazelle Court, Carlsbad, CA 92010, USA.
  • Revenko A; Department of Antisense Drug Discovery, Ionis Pharmaceuticals, Inc. 2855 Gazelle Court, Carlsbad, CA 92010, USA.
  • Kinberger GA; Department of Medicinal Chemistry, Ionis Pharmaceuticals, Inc. 2855 Gazelle Court, Carlsbad, CA 92010, USA.
  • Prakash TP; Department of Medicinal Chemistry, Ionis Pharmaceuticals, Inc. 2855 Gazelle Court, Carlsbad, CA 92010, USA.
  • Seth PP; Department of Medicinal Chemistry, Ionis Pharmaceuticals, Inc. 2855 Gazelle Court, Carlsbad, CA 92010, USA.
Nucleic Acids Res ; 45(21): 12388-12400, 2017 Dec 01.
Article en En | MEDLINE | ID: mdl-29069408
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Texto completo: 1 Colección: 01-internacional Asunto principal: Acetilgalactosamina / Oligonucleótidos Antisentido / Hepatocitos / Receptor de Asialoglicoproteína / Oligonucleótidos Fosforotioatos Límite: Animals / Humans / Male Idioma: En Revista: Nucleic Acids Res Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Asunto principal: Acetilgalactosamina / Oligonucleótidos Antisentido / Hepatocitos / Receptor de Asialoglicoproteína / Oligonucleótidos Fosforotioatos Límite: Animals / Humans / Male Idioma: En Revista: Nucleic Acids Res Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos