Long term exposure to cadmium: Pathological effects on kidney tubules cells in Sparus aurata juveniles.
Aquat Toxicol
; 193: 201-209, 2017 Dec.
Article
en En
| MEDLINE
| ID: mdl-29096093
ABSTRACT
The effects of an exposure to cadmium chloride 0.47µM for 150days were studied in kidneys of juveniles Sparus aurata by a multidisciplinary approach so to correlate uptake and detoxification potential to changes in brush border and glycocalyx sugar composition. Results demonstrated that cadmium concentration in kidney significantly increased from day 30 reaching a plateau on day 120 while metallothioneins reached a peak on day 90 and by day 120 were already decreasing to control values. Cytological damage was extensive on day 90, clearly detectable at both structural and ultrastructural levels, in tubular cells and brush-border. Staining with a panel of four lectins revealed a significant increase in N-Ac-Gal and a decrease in mannose in the glycocalyx and the tubular basal membranes. From day 120, when cadmium concentration was high and metallothionein concentration decreasing, a clear recovery was observed in tubular cells morphology and sugar composition. Possible significance of these apparently contrasting data are discussed.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Contaminantes Químicos del Agua
/
Cloruro de Cadmio
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Dorada
/
Riñón
/
Túbulos Renales
Límite:
Animals
Idioma:
En
Revista:
Aquat Toxicol
Asunto de la revista:
BIOLOGIA
/
TOXICOLOGIA
Año:
2017
Tipo del documento:
Article
País de afiliación:
Italia