Identification of mannose receptor and CD163 as novel biomarkers for colorectal cancer.
Cancer Biomark
; 21(3): 689-700, 2018 Feb 14.
Article
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| MEDLINE
| ID: mdl-29226859
ABSTRACT
The aim of present study was to investigate the clinical significances of mannose receptor (MR) and CD163 in colorectal cancer (CRC). Enzyme-linked immunosorbent assay (ELISA) and immunohistochemistry (IHC) were utilized for this analysis. Preoperative serum MR and CD163 levels ranged from 0.153 to 0.804 µg/ml (median = 0.359 µg/ml) and from 0.319 to 1.314 µg/ml (median = 0.685 µg/ml) in CRC patients respectively. Strikingly, preoperative serum levels of MR and CD163 were significantly increased in CRC patients than in healthy individuals (P< 0.0001). ROC analyses suggested that the optimum diagnostic cut-offs for serum MR and CD163 were 0.3485 µg/ml (AUC 0.7205, sensitivity 54.82%, and specificity 80.46%) and 0.6111 µg/ml (AUC 0.7463, sensitivity 62.65%, and specificity 80.46%) respectively. Detection of serum MR and CD163 together obviously enhanced the diagnostic accuracy (AUC 0.7968, sensitivity 69.28%, and specificity 77.01%). Then, preoperative serum MR and CD163 levels correlated significantly with serum CEA, CA19-9 and CA72-4 concentrations in CRC patients (P< 0.05). High MR and CD163 expression in serum was associated significantly with shorter overall survival (P< 0.05) and demonstrated as adversely prognostic factors (P< 0.05). Further, expression of MR and CD163 in CRC tissues was significantly higher than that in para-cancer tissues (P< 0.001). High expression of MR and CD163 in CRC tissues also correlated significantly with shorter overall survival (P< 0.05). MR and CD163 expression in serum or CRC tissues all correlated positively with the degree of lymphatic metastasis (P< 0.0001). In conclusion, MR and CD163 may be novel biomarkers for CRC patients.
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Texto completo:
1
Colección:
01-internacional
Asunto principal:
Antígenos de Diferenciación Mielomonocítica
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Neoplasias Colorrectales
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Biomarcadores de Tumor
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Antígenos CD
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Receptores de Superficie Celular
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Lectinas Tipo C
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Lectinas de Unión a Manosa
Tipo de estudio:
Diagnostic_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Cancer Biomark
Asunto de la revista:
BIOQUIMICA
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NEOPLASIAS
Año:
2018
Tipo del documento:
Article
País de afiliación:
China