Altered Bone Remodeling in Psoriatic Disease: New Insights and Future Directions.
Calcif Tissue Int
; 102(5): 559-574, 2018 05.
Article
en En
| MEDLINE
| ID: mdl-29330560
ABSTRACT
Psoriatic arthritis (PsA) is an inflammatory rheumatic disorder that occurs in patients with psoriasis and predominantly affects musculoskeletal structures, skin, and nails. The etiology of PsA is not well understood but evidence supports an interplay of genetic, immunologic, and environmental factors which promote pathological bone remodeling and joint damage in PsA. Localized and systemic bone loss due to increased activity of osteoclasts is well established in PsA based on animal models and translational studies. In contrast, the mechanisms responsible for pathological bone remodeling in PsA remain enigmatic although new candidate molecules and pathways have been identified. Recent reports have revealed novel findings related to bone erosion and pathologic bone formation in PsA. Many associated risk factors and contributing molecular mechanisms have also been identified. In this review, we discuss new developments in the field, point out unresolved questions regarding the pathogenetic origins of the wide array of bone phenotypes in PsA, and discuss new directions for investigation.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Huesos
/
Resorción Ósea
/
Artritis Psoriásica
/
Remodelación Ósea
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Calcif Tissue Int
Año:
2018
Tipo del documento:
Article
País de afiliación:
Estados Unidos