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2 H-1,2,3-Triazole-Based Dipeptidyl Nitriles: Potent, Selective, and Trypanocidal Rhodesain Inhibitors by Structure-Based Design.
Giroud, Maude; Kuhn, Bernd; Saint-Auret, Sarah; Kuratli, Christoph; Martin, Rainer E; Schuler, Franz; Diederich, François; Kaiser, Marcel; Brun, Reto; Schirmeister, Tanja; Haap, Wolfgang.
Afiliación
  • Giroud M; Laboratorium für Organische Chemie , ETH Zurich , Vladimir-Prelog-Weg 3 , 8093 Zürich , Switzerland.
  • Kuhn B; Roche Pharma Research and Early Development (pRED), Roche Innovation Center Basel , F. Hoffmann-La Roche Ltd. , Grenzacherstrasse 124 , 4070 Basel , Switzerland.
  • Saint-Auret S; Roche Pharma Research and Early Development (pRED), Roche Innovation Center Basel , F. Hoffmann-La Roche Ltd. , Grenzacherstrasse 124 , 4070 Basel , Switzerland.
  • Kuratli C; Roche Pharma Research and Early Development (pRED), Roche Innovation Center Basel , F. Hoffmann-La Roche Ltd. , Grenzacherstrasse 124 , 4070 Basel , Switzerland.
  • Martin RE; Roche Pharma Research and Early Development (pRED), Roche Innovation Center Basel , F. Hoffmann-La Roche Ltd. , Grenzacherstrasse 124 , 4070 Basel , Switzerland.
  • Schuler F; Roche Pharma Research and Early Development (pRED), Roche Innovation Center Basel , F. Hoffmann-La Roche Ltd. , Grenzacherstrasse 124 , 4070 Basel , Switzerland.
  • Diederich F; Laboratorium für Organische Chemie , ETH Zurich , Vladimir-Prelog-Weg 3 , 8093 Zürich , Switzerland.
  • Kaiser M; Swiss Tropical and Public Health Institute , Socinstrasse 57 , 4051 Basel , Switzerland.
  • Brun R; University of Basel , Petersplatz 1 , 4003 Basel , Switzerland.
  • Schirmeister T; Swiss Tropical and Public Health Institute , Socinstrasse 57 , 4051 Basel , Switzerland.
  • Haap W; University of Basel , Petersplatz 1 , 4003 Basel , Switzerland.
J Med Chem ; 61(8): 3370-3388, 2018 04 26.
Article en En | MEDLINE | ID: mdl-29590751
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Texto completo: 1 Colección: 01-internacional Asunto principal: Triazoles / Tripanocidas / Cisteína Endopeptidasas / Inhibidores de Cisteína Proteinasa / Dipéptidos / Nitrilos Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2018 Tipo del documento: Article País de afiliación: Suiza
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Texto completo: 1 Colección: 01-internacional Asunto principal: Triazoles / Tripanocidas / Cisteína Endopeptidasas / Inhibidores de Cisteína Proteinasa / Dipéptidos / Nitrilos Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2018 Tipo del documento: Article País de afiliación: Suiza