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First-in human, phase 1, dose-escalation pharmacokinetic and pharmacodynamic study of the oral dual PI3K and mTORC1/2 inhibitor PQR309 in patients with advanced solid tumors (SAKK 67/13).
Wicki, Andreas; Brown, Nicholas; Xyrafas, Alexandros; Bize, Vincent; Hawle, Hanne; Berardi, Simona; Cmiljanovic, Natasa; Cmiljanovic, Vladimir; Stumm, Michael; Dimitrijevic, Sasa; Herrmann, Richard; Prêtre, Vincent; Ritschard, Reto; Tzankov, Alexandar; Hess, Viviane; Childs, Alexa; Hierro, Cinta; Rodon, Jordi; Hess, Dagmar; Joerger, Markus; von Moos, Roger; Sessa, Cristiana; Kristeleit, Rebecca.
Afiliación
  • Wicki A; University Hospital Basel, Division of Oncology, Dept. of Biomedicine, Petersgraben 4, 4031 Basel, Switzerland. Electronic address: andreas.wicki@usb.ch.
  • Brown N; University College London Hospitals NHS Trust, Gynecological Oncology Team, 235 Euston Road, London NW1 2BU, United Kingdom.
  • Xyrafas A; SAKK Coordinating Center, Effingerstrasse 33, 3008 Bern, Switzerland.
  • Bize V; SAKK Coordinating Center, Effingerstrasse 33, 3008 Bern, Switzerland.
  • Hawle H; SAKK Coordinating Center, Effingerstrasse 33, 3008 Bern, Switzerland.
  • Berardi S; SAKK Coordinating Center, Effingerstrasse 33, 3008 Bern, Switzerland.
  • Cmiljanovic N; Piqur Therapeutics AG, Hochbergstrasse 60C, 4057 Basel, Switzerland.
  • Cmiljanovic V; Piqur Therapeutics AG, Hochbergstrasse 60C, 4057 Basel, Switzerland.
  • Stumm M; Piqur Therapeutics AG, Hochbergstrasse 60C, 4057 Basel, Switzerland.
  • Dimitrijevic S; Piqur Therapeutics AG, Hochbergstrasse 60C, 4057 Basel, Switzerland.
  • Herrmann R; Piqur Therapeutics AG, Hochbergstrasse 60C, 4057 Basel, Switzerland.
  • Prêtre V; University Hospital Basel, Dept. of Biomedicine, Petersgraben 4, 4031 Basel, Switzerland.
  • Ritschard R; University Hospital Basel, Dept. of Biomedicine, Petersgraben 4, 4031 Basel, Switzerland.
  • Tzankov A; University Hospital Basel, Dept. of Pathology, Schönbeinstrasse 40, 4056 Basel, Switzerland.
  • Hess V; University Hospital Basel, Division of Oncology, Dept. of Biomedicine, Petersgraben 4, 4031 Basel, Switzerland.
  • Childs A; University College London Hospitals NHS Trust, Gynecological Oncology Team, 235 Euston Road, London NW1 2BU, United Kingdom.
  • Hierro C; Vall d'Hebron Institut d'Oncologia, Universitat Autonoma of Barcelona, Passeig Vall d'Hebron 119-129, 08035 Barcelona, Spain.
  • Rodon J; Vall d'Hebron Institut d'Oncologia, Universitat Autonoma of Barcelona, Passeig Vall d'Hebron 119-129, 08035 Barcelona, Spain.
  • Hess D; Cantonal Hospital St. Gallen, Dept. of Oncology and Hematology, Rorschacherstrasse 95, 9007 St. Gallen, Switzerland.
  • Joerger M; Cantonal Hospital St. Gallen, Dept. of Oncology and Hematology, Rorschacherstrasse 95, 9007 St. Gallen, Switzerland.
  • von Moos R; Cantonal Hospital Graubünden, Dept. of Oncology and Hematology, Loestrasse 170, 7000 Chur, Switzerland.
  • Sessa C; Istituto Oncologico della Svizzera Italiana, Ospedale San Giovanni, 6500 Bellinzona, Switzerland.
  • Kristeleit R; University College London Hospitals NHS Trust, Gynecological Oncology Team, 235 Euston Road, London NW1 2BU, United Kingdom.
Eur J Cancer ; 96: 6-16, 2018 06.
Article en En | MEDLINE | ID: mdl-29660598
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Texto completo: 1 Colección: 01-internacional Asunto principal: Inhibidores de Proteínas Quinasas / Diana Mecanicista del Complejo 1 de la Rapamicina / Diana Mecanicista del Complejo 2 de la Rapamicina / Inhibidores de las Quinasa Fosfoinosítidos-3 / Neoplasias / Antineoplásicos Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Eur J Cancer Año: 2018 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Asunto principal: Inhibidores de Proteínas Quinasas / Diana Mecanicista del Complejo 1 de la Rapamicina / Diana Mecanicista del Complejo 2 de la Rapamicina / Inhibidores de las Quinasa Fosfoinosítidos-3 / Neoplasias / Antineoplásicos Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Eur J Cancer Año: 2018 Tipo del documento: Article