Allergic Rhinitis in Rats Is Associated with an Inflammatory Response of the Hippocampus.
Behav Neurol
; 2018: 8750464, 2018.
Article
en En
| MEDLINE
| ID: mdl-29849816
ABSTRACT
Allergic rhinitis (AR) is a major concern in personal and public health, which negatively affects emotions and behavior, leading to cognitive deficits, memory decline, poor school performance, anxiety, and depression. Several cellular and molecular mediators are released in the inflammatory process of AR and activate common neuroimmune mechanisms, involving emotionally relevant circuits and the induction of anxiety. Responsiveness of the hypothalamic-pituitary-adrenal (HPA) axis to allergic processes have been reported, which may also include responsiveness of the hippocampus, cortex, and other brain regions. Here, we have used an optimized rat model of AR to explore whether the disease has a relationship with inflammatory responses in the hippocampus. AR was established in adult rats by ovalbumin sensitization, and the expression of various inflammatory substances in the hippocampus was measured by specific assays. Comparison between experimental and various control groups of animals revealed an association of AR with significant upregulation of substance P, microglia surface antigen (CD11b), glial fibrillary acid protein (GFAP), tumor necrosis factor-α (TNF-α), and interleukin 6 (IL-6) in the hippocampus. Thus, we hypothesize that the AR challenge may activate these inflammatory mediators in the hippocampus, which in turn contribute to the abnormal behavior and neurological deficits associated with AR.
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Sustancia P
/
Interleucina-6
/
Factor de Necrosis Tumoral alfa
/
Antígenos CD11
/
Rinitis Alérgica
/
Proteína Ácida Fibrilar de la Glía
/
Hipocampo
/
Inflamación
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Límite:
Animals
Idioma:
En
Revista:
Behav Neurol
Asunto de la revista:
CIENCIAS DO COMPORTAMENTO
/
NEUROLOGIA
Año:
2018
Tipo del documento:
Article
País de afiliación:
China