Studies directed toward the asialoglycoprotein receptor mediated delivery of 5-fluoro-2'-deoxyuridine for hepatocellular carcinoma.

Rico, Lorena; Østergaard, Michael E; Bell, Melanie; Seth, Punit P; Hanessian, Stephen

Rico, Lorena; Østergaard, Michael E; Bell, Melanie; Seth, Punit P; Hanessian, Stephen.

Afiliación

Rico L; Department of Chemistry, Université de Montréal, C.P. 6128, Succursale Centre-ville, Montréal, Québec H3C 3J7, Canada.
Østergaard ME; Department of Medicinal Chemistry, Ionis Pharmaceuticals, Inc. 2855 Gazelle Court, Carlsbad, CA 92010, USA.
Bell M; Department of Antisense Drug Discovery, Ionis Pharmaceuticals, Inc. 2855 Gazelle Court, Carlsbad, CA 92010, USA.
Seth PP; Department of Medicinal Chemistry, Ionis Pharmaceuticals, Inc. 2855 Gazelle Court, Carlsbad, CA 92010, USA.
Hanessian S; Department of Chemistry, Université de Montréal, C.P. 6128, Succursale Centre-ville, Montréal, Québec H3C 3J7, Canada. Electronic address: Stephen.hanessian@umontreal.ca.

Bioorg Med Chem Lett ; 28(15): 2652-2654, 2018 08 15.

Article en En | MEDLINE | ID: mdl-30042045

ABSTRACT

ABSTRACT

The anticancer nucleoside 5-fluoro 2'-deoxyuridine-5'-phosphate (5-FdU-P) was attached via an amide chain linker to a triantennary GalNAc cluster as a means to deliver the drug to hepatic cells that recognize the amino sugar units.

Asunto(s)

Antineoplásicos/administración & dosificación; Receptor de Asialoglicoproteína/metabolismo; Carcinoma Hepatocelular/tratamiento farmacológico; Desoxiuridina/análogos & derivados; Neoplasias Hepáticas/tratamiento farmacológico; Antineoplásicos/uso terapéutico; Desoxiuridina/administración & dosificación; Desoxiuridina/uso terapéutico; Sistemas de Liberación de Medicamentos; Células Hep G2; Humanos; Fosforilación; Profármacos/administración & dosificación

Palabras clave

Drug delivery; GalNAc cluster; Liver cancer; Nucleoside; Phosphoramidite

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Texto completo: 1 Colección: 01-internacional Asunto principal: Carcinoma Hepatocelular / Receptor de Asialoglicoproteína / Desoxiuridina / Neoplasias Hepáticas / Antineoplásicos Límite: Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2018 Tipo del documento: Article País de afiliación: Canadá

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