Therapeutic effects of bee venom on experimental atopic dermatitis.
Mol Med Rep
; 18(4): 3711-3718, 2018 Oct.
Article
en En
| MEDLINE
| ID: mdl-30132547
ABSTRACT
Atopic dermatitis (AD) is a chronic skin inflammatory disease characterized by recurrent eczema and itching. It is caused by a poorly controlled immune response and damage to the skin barrier. Purified bee venom (BV) is a natural toxin produced by honeybees (Apis mellifera L.), and is well known for its antiinflammatory, analgesic and anticancer effects against various types of disease. However, treatment strategies based on antiinflammatory properties have not been adequately studied in AD. Thus, the present study examined the progression of ADlike skin lesions induced by ovalbumin (OVA) and the mechanism of action of BV. BV, administered by intraperitoneal inoculation, was observed to reduce the symptoms of AD, in addition to the serum immunoglobulin E levels, according to dorsal skin thickness and histopathologic analysis. The treatment also inhibited the infiltration of eosinophils and mast cells. These results suggested that it is possible to develop novel AD alternative therapy using BV by effectively suppressing allergic skin inflammation in AD.
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Piel
/
Venenos de Abeja
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Dermatitis Atópica
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Antiinflamatorios
Límite:
Animals
Idioma:
En
Revista:
Mol Med Rep
Año:
2018
Tipo del documento:
Article