Initiation and Evolution of Early Onset Prostate Cancer.

Russo, Joshua W; Balk, Steven P

Russo, Joshua W; Balk, Steven P.

Afiliación

Russo JW; Hematology-Oncology Division, Department of Medicine and Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Balk SP; Hematology-Oncology Division, Department of Medicine and Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. Electronic address: sbalk@bidmc.harvard.edu.

Cancer Cell ; 34(6): 874-876, 2018 12 10.

Article en En | MEDLINE | ID: mdl-30537509

ABSTRACT

ABSTRACT

In this issue of Cancer Cell, Gerhauser et al. analyze early-onset prostate cancers, showing roles for androgen receptor-driven rearrangements, an early APOBEC-driven mutational mechanism, and ESRP1 gene duplication. Through integration of whole-genome, transcriptome, and methylome data, they identify high-risk subgroups and develop an algorithm that may predict molecular evolution.

Asunto(s)

Neoplasias de la Próstata; Receptores Androgénicos/genética; Evolución Molecular; Humanos; Masculino; Mutación; Transcriptoma

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Texto completo: 1 Colección: 01-internacional Asunto principal: Neoplasias de la Próstata / Receptores Androgénicos Tipo de estudio: Prognostic_studies Límite: Humans / Male Idioma: En Revista: Cancer Cell Asunto de la revista: NEOPLASIAS Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos

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