Natural modulators of the hallmarks of immunogenic cell death.
Biochem Pharmacol
; 162: 55-70, 2019 04.
Article
en En
| MEDLINE
| ID: mdl-30615863
ABSTRACT
Natural compounds act as immunoadjuvants as their therapeutic effects trigger cancer stress response and release of damage-associated molecular patterns (DAMPs). These reactions occur through an increase in the immunogenicity of cancer cells that undergo stress followed by immunogenic cell death (ICD). These processes result in a chemotherapeutic response with a potent immune-mediating reaction. Natural compounds that induce ICD may function as an interesting approach in converting cancer into its own vaccine. However, multiple parameters determine whether a compound can act as an ICD inducer, including the nature of the inducer, the premortem stress pathways, the cell death pathways, the intrinsic antigenicity of the cell, and the potency and availability of an immune cell response. Thus, the identification of hallmarks of ICD is important in determining the prognostic biomarkers for new therapeutic approaches and combination treatments.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Muerte Celular Inmunogénica
/
Inmunidad Celular
/
Inmunoterapia
/
Neoplasias
/
Antineoplásicos Fitogénicos
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Biochem Pharmacol
Año:
2019
Tipo del documento:
Article
País de afiliación:
Luxemburgo