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2-Aminothiazole Derivatives as Selective Allosteric Modulators of the Protein Kinase CK2. 1. Identification of an Allosteric Binding Site.
Bestgen, Benoît; Krimm, Isabelle; Kufareva, Irina; Kamal, Ahmed Ashraf Moustafa; Seetoh, Wei-Guang; Abell, Chris; Hartmann, Rolf W; Abagyan, Ruben; Cochet, Claude; Le Borgne, Marc; Engel, Matthias; Lomberget, Thierry.
Afiliación
  • Bestgen B; Pharmaceutical and Medicinal Chemistry , Saarland University , Campus C2.3, 66123 Saarbrücken , Germany.
  • Krimm I; Université de Lyon, Université Lyon 1, Faculté de Pharmacie, ISPB, EA 4446 Bioactive Molecules and Medicinal Chemistry, SFR Santé Lyon-Est CNRS UMS3453, INSERM US7, F-69373 , Lyon Cedex 08, France.
  • Kufareva I; Institut National de la Santé et de la Recherche Médicale , U1036, 38000 Grenoble , France.
  • Kamal AAM; Institute of Life Sciences Research and Technologies, Biology of Cancer and Infection, Commissariat à l'Energie Atomique, 38000 Grenoble , France.
  • Seetoh WG; Unité Mixte de Recherche-S1036 , University of Grenoble Alpes , 38000 Grenoble , France.
  • Abell C; Institut des Sciences Analytiques, UMR 5280, Université de Lyon, CNRS, Université Lyon 1, ENS Lyon 5, Rue de la Doua , 69100 Villeurbanne , France.
  • Hartmann RW; Skaggs School of Pharmacy and Pharmaceutical Sciences , University of California, San Diego , La Jolla , California 92093 , United States.
  • Abagyan R; Pharmaceutical and Medicinal Chemistry, Saarland University, and Department of Drug Design and Optimization, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Campus C2.3, 66123 Saarbrücken , Germany.
  • Cochet C; Department of Chemistry , University of Cambridge , Lensfield Road , Cambridge CB2 1EW , United Kingdom.
  • Le Borgne M; Department of Chemistry , University of Cambridge , Lensfield Road , Cambridge CB2 1EW , United Kingdom.
  • Engel M; Pharmaceutical and Medicinal Chemistry, Saarland University, and Department of Drug Design and Optimization, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Campus C2.3, 66123 Saarbrücken , Germany.
  • Lomberget T; Skaggs School of Pharmacy and Pharmaceutical Sciences , University of California, San Diego , La Jolla , California 92093 , United States.
J Med Chem ; 62(4): 1803-1816, 2019 02 28.
Article en En | MEDLINE | ID: mdl-30689953
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Texto completo: 1 Colección: 01-internacional Asunto principal: Tiazoles / Quinasa de la Caseína II / Inhibidores de Proteínas Quinasas Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2019 Tipo del documento: Article País de afiliación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Asunto principal: Tiazoles / Quinasa de la Caseína II / Inhibidores de Proteínas Quinasas Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2019 Tipo del documento: Article País de afiliación: Alemania