Usefulness of Gastric Aspirate Culture for Diagnosing Congenital Immunodeficiency in an Infant with Fungal Pneumonia Caused by Rasamsonia piperina.
Tohoku J Exp Med
; 247(4): 265-269, 2019 04.
Article
en En
| MEDLINE
| ID: mdl-31006737
ABSTRACT
Chronic granulomatous disease (CGD) is a type of primary immunodeficiency disease, which increases susceptibility to recurrent bacterial and fungal infections. Sputum and bronchoalveolar lavage fluid are often obtained using bronchoscopy from adult patients for pathogenic diagnosis, although this approach is much more invasive for infants. We report the case of a 2-month-old boy with CGD, in which gastric aspirate culture was used to diagnose fungal pneumonia. Rasamsonia piperina was isolated from the gastric aspirate, and the patient was successfully treated with micafungin based on the drug susceptibility test results for the fungal isolate. The acid tolerance test revealed that R. piperina could grow at pH 2, indicating high acid resistance. Although we can only report our experience with a single case, gastric aspirate culture may be a useful tool for detecting fungal respiratory pathogens in children with primary immunodeficiency. Detecting these pathogens may help improve outcomes, as early diagnosis and appropriate treatment are extremely important for immunocompromised patients with respiratory infections.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Neumonía
/
Ascomicetos
/
Estómago
/
Síndromes de Inmunodeficiencia
/
Micosis
Tipo de estudio:
Diagnostic_studies
/
Screening_studies
Límite:
Humans
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Infant
Idioma:
En
Revista:
Tohoku J Exp Med
Año:
2019
Tipo del documento:
Article