Human umbilical cord blood cells restore vascular integrity in injured rat brain and modulate inflammation in vitro.
Regen Med
; 14(4): 295-307, 2019 05.
Article
en En
| MEDLINE
| ID: mdl-31074319
ABSTRACT
Aim:
Traumatic brain injury is a complex condition consisting of a mechanical injury with neurovascular disruption and inflammation with limited clinical interventions available. A growing number of studies report systemic delivery of human umbilical cord blood (HUCB) as a therapy for neural injuries. Materials &methods:
HUCB cells from five donors were tested to improve blood-brain barrier integrity in a traumatic brain injury rat model at a dose of 2.5 × 107 cells/kg at 24 or 72 h postinjury and for immunomodulatory activity in vitro. Results &Conclusion:
We observed that cells delivered 72 h postinjury significantly restored blood-brain barrier integrity. HUCB cells reduced the amount of TNF-α and IFN-γ released by activated primary rat splenocytes, which correlated with the expression of COX2 and IDO1.Palabras clave
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Cordón Umbilical
/
Encéfalo
/
Lesiones Encefálicas
/
Sangre Fetal
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Inflamación
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
/
Male
Idioma:
En
Revista:
Regen Med
Año:
2019
Tipo del documento:
Article
País de afiliación:
Estados Unidos