Defining the NSD2 interactome: PARP1 PARylation reduces NSD2 histone methyltransferase activity and impedes chromatin binding.

Huang, Xiaoxiao; LeDuc, Richard D; Fornelli, Luca; Schunter, Alissa J; Bennett, Richard L; Kelleher, Neil L; Licht, Jonathan D

Huang, Xiaoxiao; LeDuc, Richard D; Fornelli, Luca; Schunter, Alissa J; Bennett, Richard L; Kelleher, Neil L; Licht, Jonathan D.

Afiliación

Huang X; Division of Hematology/Oncology, University of Florida Health Cancer Center, Gainesville, Florida 32608; Department of Chemistry and the Department of Molecular Biosciences, and the Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois 60208.
LeDuc RD; Department of Chemistry and the Department of Molecular Biosciences, and the Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois 60208.
Fornelli L; Department of Chemistry and the Department of Molecular Biosciences, and the Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois 60208.
Schunter AJ; Department of Chemistry and the Department of Molecular Biosciences, and the Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois 60208.
Bennett RL; Division of Hematology/Oncology, University of Florida Health Cancer Center, Gainesville, Florida 32608.
Kelleher NL; Department of Chemistry and the Department of Molecular Biosciences, and the Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois 60208.
Licht JD; Division of Hematology/Oncology, University of Florida Health Cancer Center, Gainesville, Florida 32608. Electronic address: jdlicht@ufl.edu.

J Biol Chem ; 294(33): 12459-12471, 2019 08 16.

Article en En | MEDLINE | ID: mdl-31248990

Asunto(s)

Cromatina/enzimología; N-Metiltransferasa de Histona-Lisina/metabolismo; Mieloma Múltiple/enzimología; Proteínas de Neoplasias/metabolismo; Poli(ADP-Ribosa) Polimerasa-1/metabolismo; Poli ADP Ribosilación; Proteínas Represoras/metabolismo; Línea Celular Tumoral; Cromatina/genética; Cromatina/patología; Roturas del ADN de Doble Cadena; N-Metiltransferasa de Histona-Lisina/genética; Histonas/genética; Histonas/metabolismo; Humanos; Mieloma Múltiple/genética; Mieloma Múltiple/patología; Proteínas de Neoplasias/genética; Estrés Oxidativo/genética; Poli(ADP-Ribosa) Polimerasa-1/genética; Proteínas Represoras/genética

Palabras clave

DNA damage; NSD2; PARP1; PARylation; epigenetics; histone methylation; protein complex; proteomics

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Texto completo: 1 Colección: 01-internacional Asunto principal: Proteínas Represoras / Cromatina / N-Metiltransferasa de Histona-Lisina / Poli(ADP-Ribosa) Polimerasa-1 / Poli ADP Ribosilación / Mieloma Múltiple / Proteínas de Neoplasias Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: J Biol Chem Año: 2019 Tipo del documento: Article

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