Deregulated MTOR (mechanistic target of rapamycin kinase) is responsible for autophagy defects exacerbating kidney stone development.

Unno, Rei; Kawabata, Tsuyoshi; Taguchi, Kazumi; Sugino, Teruaki; Hamamoto, Shuzo; Ando, Ryosuke; Okada, Atsushi; Kohri, Kenjiro; Yoshimori, Tamotsu; Yasui, Takahiro

Unno, Rei; Kawabata, Tsuyoshi; Taguchi, Kazumi; Sugino, Teruaki; Hamamoto, Shuzo; Ando, Ryosuke; Okada, Atsushi; Kohri, Kenjiro; Yoshimori, Tamotsu; Yasui, Takahiro.

Afiliación

Unno R; Department of Nephro-urology, Nagoya City University Graduate School of Medical Sciences, Aichi, Japan.
Kawabata T; Department of Stem Cell Biology, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, Japan.
Taguchi K; Department of Nephro-urology, Nagoya City University Graduate School of Medical Sciences, Aichi, Japan.
Sugino T; Department of Nephro-urology, Nagoya City University Graduate School of Medical Sciences, Aichi, Japan.
Hamamoto S; Department of Nephro-urology, Nagoya City University Graduate School of Medical Sciences, Aichi, Japan.
Ando R; Department of Nephro-urology, Nagoya City University Graduate School of Medical Sciences, Aichi, Japan.
Okada A; Department of Nephro-urology, Nagoya City University Graduate School of Medical Sciences, Aichi, Japan.
Kohri K; Department of Nephro-urology, Nagoya City University Graduate School of Medical Sciences, Aichi, Japan.
Yoshimori T; Department of Genetics, Osaka University Graduate School of Medicine, Osaka, Japan.
Yasui T; Department of Nephro-urology, Nagoya City University Graduate School of Medical Sciences, Aichi, Japan.

Autophagy ; 16(4): 709-723, 2020 04.

Article en En | MEDLINE | ID: mdl-31257986

Asunto(s)

Autofagia/efectos de los fármacos; Cálculos Renales/tratamiento farmacológico; Mitocondrias/efectos de los fármacos; Sirolimus/farmacología; Animales; Cálculos Renales/metabolismo; Lisosomas/efectos de los fármacos; Lisosomas/metabolismo; Ratones Endogámicos C57BL; Ratones Transgénicos; Mitocondrias/metabolismo; Especies Reactivas de Oxígeno/metabolismo; Transducción de Señal/efectos de los fármacos; Serina-Treonina Quinasas TOR/metabolismo

Palabras clave

Autophagy; calcium oxalate; kidney stone; mechanistic target of rapamycin kinase; transcription factor EB

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Asunto principal: Autofagia / Cálculos Renales / Sirolimus / Mitocondrias Límite: Animals Idioma: En Revista: Autophagy Año: 2020 Tipo del documento: Article País de afiliación: Japón

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google