Computer-aided design and synthesis of 3-carbonyl-5-phenyl-1<i>H</i>-pyrazole as highly selective and potent BRAFV600E and CRAF inhibitor.

Kim, Jinwoong; Choi, Byeongha; Im, Daseul; Jung, Hoyong; Moon, Hyungwoo; Aman, Waqar; Hah, Jung-Mi

Computer-aided design and synthesis of 3-carbonyl-5-phenyl-1H-pyrazole as highly selective and potent BRAFV600E and CRAF inhibitor.

Kim, Jinwoong; Choi, Byeongha; Im, Daseul; Jung, Hoyong; Moon, Hyungwoo; Aman, Waqar; Hah, Jung-Mi.

Afiliación

Kim J; a Department of Pharmacy and Institute of Pharmaceutical Science and Technology , College of Pharmacy, Hanyang University , Ansan , Gyunggido, Republic of Korea.
Choi B; a Department of Pharmacy and Institute of Pharmaceutical Science and Technology , College of Pharmacy, Hanyang University , Ansan , Gyunggido, Republic of Korea.
Im D; a Department of Pharmacy and Institute of Pharmaceutical Science and Technology , College of Pharmacy, Hanyang University , Ansan , Gyunggido, Republic of Korea.
Jung H; a Department of Pharmacy and Institute of Pharmaceutical Science and Technology , College of Pharmacy, Hanyang University , Ansan , Gyunggido, Republic of Korea.
Moon H; a Department of Pharmacy and Institute of Pharmaceutical Science and Technology , College of Pharmacy, Hanyang University , Ansan , Gyunggido, Republic of Korea.
Aman W; b Kohat University of Science and Technology , Kohat , Khyber Pukhtunkhwa , Pakistan.
Hah JM; a Department of Pharmacy and Institute of Pharmaceutical Science and Technology , College of Pharmacy, Hanyang University , Ansan , Gyunggido, Republic of Korea.

J Enzyme Inhib Med Chem ; 34(1): 1314-1320, 2019 Dec.

Article en En | MEDLINE | ID: mdl-31307243

Asunto(s)

Diseño Asistido por Computadora; Inhibidores de Proteínas Quinasas/farmacología; Proteínas Proto-Oncogénicas B-raf/antagonistas & inhibidores; Pirazoles/farmacología; Relación Dosis-Respuesta a Droga; Humanos; Estructura Molecular; Inhibidores de Proteínas Quinasas/síntesis química; Inhibidores de Proteínas Quinasas/química; Proteínas Proto-Oncogénicas B-raf/metabolismo; Pirazoles/síntesis química; Pirazoles/química; Relación Estructura-Actividad

Palabras clave

BRAFV600E; BRAFWT; CRAF; Melanoma; selectivity

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Asunto principal: Pirazoles / Diseño Asistido por Computadora / Proteínas Proto-Oncogénicas B-raf / Inhibidores de Proteínas Quinasas Límite: Humans Idioma: En Revista: J Enzyme Inhib Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2019 Tipo del documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google