Exploiting Arginine Auxotrophy with Pegylated Arginine Deiminase (ADI-PEG20) to Sensitize Pancreatic Cancer to Radiotherapy via Metabolic Dysregulation.

Singh, Pankaj K; Deorukhkar, Amit A; Venkatesulu, Bhanu P; Li, Xiaolin; Tailor, Ramesh; Bomalaski, John S; Krishnan, Sunil

Singh, Pankaj K; Deorukhkar, Amit A; Venkatesulu, Bhanu P; Li, Xiaolin; Tailor, Ramesh; Bomalaski, John S; Krishnan, Sunil.

Afiliación

Singh PK; Department of Experimental Radiation Oncology, MD Anderson Cancer Center, Houston, Texas.
Deorukhkar AA; Department of Experimental Radiation Oncology, MD Anderson Cancer Center, Houston, Texas.
Venkatesulu BP; Department of Experimental Radiation Oncology, MD Anderson Cancer Center, Houston, Texas.
Li X; Department of Experimental Radiation Oncology, MD Anderson Cancer Center, Houston, Texas.
Tailor R; Department of Radiation Physics, MD Anderson Cancer Center, Houston, Texas.
Bomalaski JS; Polaris Pharmaceuticals, Inc., San Diego, California.
Krishnan S; Department of Experimental Radiation Oncology, MD Anderson Cancer Center, Houston, Texas. skrishnan@mdanderson.org.

Mol Cancer Ther ; 18(12): 2381-2393, 2019 12.

Article en En | MEDLINE | ID: mdl-31395686

Asunto(s)

Arginina/uso terapéutico; Hidrolasas/uso terapéutico; Neoplasias Pancreáticas/tratamiento farmacológico; Neoplasias Pancreáticas/radioterapia; Polietilenglicoles/uso terapéutico; Animales; Línea Celular Tumoral; Modelos Animales de Enfermedad; Humanos; Hidrolasas/farmacología; Ratones; Neoplasias Pancreáticas/patología; Polietilenglicoles/farmacología

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Texto completo: 1 Colección: 01-internacional Asunto principal: Neoplasias Pancreáticas / Arginina / Polietilenglicoles / Hidrolasas Límite: Animals / Humans Idioma: En Revista: Mol Cancer Ther Asunto de la revista: ANTINEOPLASICOS Año: 2019 Tipo del documento: Article

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