Long Non-coding RNAs: Regulators of the Activity of Myeloid-Derived Suppressor Cells.
Front Immunol
; 10: 1734, 2019.
Article
en En
| MEDLINE
| ID: mdl-31404149
ABSTRACT
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous cell population with potent immunosuppressive functions. They play major roles in cancer and many of the pathologic conditions associated with inflammation. Long non-coding RNAs (lncRNAs) are untranslated functional RNA molecules. The lncRNAs are involved in the control of a wide variety of cellular processes and are dysregulated in different diseases. They can participate in the modulation of immune function and activity of inflammatory cells, including MDSCs. This mini review focuses on the emerging role of lncRNAs in MDSC activity. We summarize how lncRNAs modulate the generation, recruitment, and immunosuppressive functions of MDSCs and the underlying mechanisms.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Asunto principal:
ARN Largo no Codificante
/
Células Supresoras de Origen Mieloide
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Inflamación
/
Neoplasias
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Front Immunol
Año:
2019
Tipo del documento:
Article
País de afiliación:
México