A novel DNA repair inhibitor, diallyl disulfide (DADS), impairs DNA resection during DNA double-strand break repair by reducing Sae2 and Exo1 levels.

Kuo, Chen-Hsin; Leu, Yann-Lii; Wang, Tong-Hong; Tseng, Wei-Che; Feng, Chun-Hao; Wang, Shu-Huei; Chen, Chin-Chuan

Kuo, Chen-Hsin; Leu, Yann-Lii; Wang, Tong-Hong; Tseng, Wei-Che; Feng, Chun-Hao; Wang, Shu-Huei; Chen, Chin-Chuan.

Afiliación

Kuo CH; Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Leu YL; Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Center for Traditional Chinese Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Wang TH; Tissue Bank, Chang Gung Memorial Hospital, Taoyuan, Taiwan; Graduate Institute of Health Industry Technology, Research Center for Industry of Human Ecology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, Taiwan; Liver Research Center, Chang Gung Memorial Hospital
Tseng WC; Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Feng CH; Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Wang SH; Department of Anatomy and Cell Biology, College of Medicine, National Taiwan University, Taipei, Taiwan.
Chen CC; Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Tissue Bank, Chang Gung Memorial Hospital, Taoyuan, Taiwan. Electronic address: chinchuan@mail.

DNA Repair (Amst) ; 82: 102690, 2019 10.

Article en En | MEDLINE | ID: mdl-31479843

Asunto(s)

Compuestos Alílicos/farmacología; Roturas del ADN de Doble Cadena/efectos de los fármacos; Reparación del ADN/efectos de los fármacos; Disulfuros/farmacología; Endonucleasas/metabolismo; Exodesoxirribonucleasas/metabolismo; Proteínas de Saccharomyces cerevisiae/metabolismo; Apoptosis/efectos de los fármacos; Apoptosis/genética; Muerte Celular Autofágica/efectos de los fármacos; Muerte Celular Autofágica/genética; Sinergismo Farmacológico; Proteolisis/efectos de los fármacos; Saccharomyces cerevisiae/citología; Saccharomyces cerevisiae/efectos de los fármacos; Saccharomyces cerevisiae/genética; Saccharomyces cerevisiae/metabolismo

Palabras clave

DNA damage checkpoint; DNA repair; DNA resection; Diallyl disulfide; Homologous recombination

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Asunto principal: Proteínas de Saccharomyces cerevisiae / Disulfuros / Reparación del ADN / Endonucleasas / Compuestos Alílicos / Exodesoxirribonucleasas / Roturas del ADN de Doble Cadena Idioma: En Revista: DNA Repair (Amst) Asunto de la revista: BIOLOGIA MOLECULAR / BIOQUIMICA Año: 2019 Tipo del documento: Article País de afiliación: Taiwán

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google