How does Helicobacter pylori cause gastric cancer through connexins: An opinion review.
World J Gastroenterol
; 25(35): 5220-5232, 2019 Sep 21.
Article
en En
| MEDLINE
| ID: mdl-31558869
ABSTRACT
Helicobacter pylori (H. pylori) is a Gram-negative bacterium with a number of virulence factors, such as cytotoxin-associated gene A, vacuolating cytotoxin A, its pathogenicity island, and lipopolysaccharide, which cause gastrointestinal diseases. Connexins function in gap junctional homeostasis, and their downregulation is closely related to gastric carcinogenesis. Investigations into H. pylori infection and the fine-tuning of connexins in cells or tissues have been reported in previous studies. Therefore, in this review, the potential mechanisms of H. pylori-induced gastric cancer through connexins are summarized in detail.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Neoplasias Gástricas
/
Helicobacter pylori
/
Infecciones por Helicobacter
/
Conexinas
/
Carcinogénesis
Límite:
Humans
Idioma:
En
Revista:
World J Gastroenterol
Asunto de la revista:
GASTROENTEROLOGIA
Año:
2019
Tipo del documento:
Article
País de afiliación:
China