Estradiol/testosterone and estradiol/androstenedione indexes and nutritional status in PCOS women - A pilot study.
Eur J Obstet Gynecol Reprod Biol
; 242: 166-169, 2019 Nov.
Article
en En
| MEDLINE
| ID: mdl-31600717
ABSTRACT
OBJECTIVE:
The aim of the study was to analyze interrelations between estradiol/testosterone (E2/T) and estradiol/androstenedione (E2/A) indexes and nutritional status, insulin resistance in PCOS. STUDYDESIGN:
A cross-sectional study involved 76 PCOS (41 obese) and 67 Non-PCOS (40 obese) women. Anthropometric parameters and body composition were assessed. In fasting state of serum glucose, androgens, estradiol, FSH, LH, SHBG and insulin were measured. E2/T and E2/A indexes and the homeostasis model assessment of insulin resistance (HOMA-IR) were calculated.RESULTS:
The values of E2/T and E2/A indexes were significantly lower in the PCOS than Non-PCOS subjects, but did not differ significantly between the obese and normal weight groups. The lowest E2/T and E2/A values were observed in the normal weight PCOS group. Multivariable regression analyses revealed that the presence of PCOS was the major factor affecting both the log10 E2/T (ß = -0.16) and log10 E2/A (ß = -0.15) indexes. In addition, log10 E2/A index variability was explained by percentage of body fat (ß = 0.57). HOMA-IR was not among the explanatory factors in all above models.COMMENT:
The E2/A index is more affected by nutritional status than E2/T index. The lower value of both indices in PCOS women with normal body mass suggest that aromatase activity in PCOS are related to nutritional status.Palabras clave
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Síndrome del Ovario Poliquístico
/
Testosterona
/
Estradiol
/
Androstenodiona
/
Obesidad
Tipo de estudio:
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Female
/
Humans
Idioma:
En
Revista:
Eur J Obstet Gynecol Reprod Biol
Año:
2019
Tipo del documento:
Article
País de afiliación:
Polonia