Conformational analysis and in vitro immunomodulatory and insulinotropic properties of the frog skin host-defense peptide rhinophrynin-27 and selected analogs.

Scorciapino, Mariano A; Carta, Paola; Pantic, Jelena; Lukic, Miodrag L; Lukic, Aleksandra; Musale, Vishal; Abdel-Wahab, Yasser H A; Conlon, J Michael

Conformational analysis and in vitro immunomodulatory and insulinotropic properties of the frog skin host-defense peptide rhinophrynin-27 and selected analogs.

Scorciapino, Mariano A; Carta, Paola; Pantic, Jelena; Lukic, Miodrag L; Lukic, Aleksandra; Musale, Vishal; Abdel-Wahab, Yasser H A; Conlon, J Michael.

Afiliación

Scorciapino MA; Department of Chemical and Geological Sciences, University of Cagliari, Cagliari, Italy.
Carta P; Department of Chemical and Geological Sciences, University of Cagliari, Cagliari, Italy.
Pantic J; Center for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.
Lukic ML; Department of Endodontics, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.
Lukic A; Department of Endodontics, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.
Musale V; Diabetes Research Group, School of Biomedical Sciences, Ulster University, Coleraine, BT52 1SA, N. Ireland, UK.
Abdel-Wahab YHA; Diabetes Research Group, School of Biomedical Sciences, Ulster University, Coleraine, BT52 1SA, N. Ireland, UK.
Conlon JM; Diabetes Research Group, School of Biomedical Sciences, Ulster University, Coleraine, BT52 1SA, N. Ireland, UK. Electronic address: m.conlon@ulster.ac.uk.

Biochimie ; 167: 198-206, 2019 Dec.

Article en En | MEDLINE | ID: mdl-31639404

Asunto(s)

Antiinflamatorios; Péptidos Catiónicos Antimicrobianos; Hipoglucemiantes; Células Secretoras de Insulina/inmunología; Proteínas Anfibias/química; Proteínas Anfibias/farmacología; Animales; Antiinflamatorios/química; Antiinflamatorios/farmacología; Péptidos Catiónicos Antimicrobianos/química; Péptidos Catiónicos Antimicrobianos/farmacología; Células Cultivadas; Hipoglucemiantes/química; Hipoglucemiantes/farmacología; Secreción de Insulina/efectos de los fármacos; Células Secretoras de Insulina/citología; Interleucina-10/metabolismo; Interleucina-1beta/metabolismo; Ratones; Ratones Endogámicos C57BL; Conformación Molecular; Relación Estructura-Actividad; Factor de Necrosis Tumoral alfa/metabolismo

Palabras clave

Anti-inflammatory; Cytokine; Frog skin; Insulin release; Rhinophrynin-27; Type 2 diabetes

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Texto completo: 1 Colección: 01-internacional Asunto principal: Péptidos Catiónicos Antimicrobianos / Células Secretoras de Insulina / Hipoglucemiantes / Antiinflamatorios Límite: Animals Idioma: En Revista: Biochimie Año: 2019 Tipo del documento: Article País de afiliación: Italia

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