JAK2 V617F -Mediated Clonal Hematopoiesis Accelerates Pathological Remodeling in Murine Heart Failure.

Sano, Soichi; Wang, Ying; Yura, Yoshimitsu; Sano, Miho; Oshima, Kosei; Yang, Yue; Katanasaka, Yasufumi; Min, Kyung-Duk; Matsuura, Shinobu; Ravid, Katya; Mohi, Golam; Walsh, Kenneth

JAK2 ^V617F -Mediated Clonal Hematopoiesis Accelerates Pathological Remodeling in Murine Heart Failure.

Sano, Soichi; Wang, Ying; Yura, Yoshimitsu; Sano, Miho; Oshima, Kosei; Yang, Yue; Katanasaka, Yasufumi; Min, Kyung-Duk; Matsuura, Shinobu; Ravid, Katya; Mohi, Golam; Walsh, Kenneth.

Afiliación

Sano S; Hematovascular Biology Center, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, Virginia.
Wang Y; Hematovascular Biology Center, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, Virginia.
Yura Y; Hematovascular Biology Center, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, Virginia.
Sano M; Hematovascular Biology Center, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, Virginia.
Oshima K; Molecular Cardiology, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts.
Yang Y; Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, Virginia.
Katanasaka Y; Division of Molecular Medicine, Graduate School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan.
Min KD; Hematovascular Biology Center, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, Virginia.
Matsuura S; Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts.
Ravid K; Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts.
Mohi G; Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, Virginia.
Walsh K; Hematovascular Biology Center, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, Virginia.

JACC Basic Transl Sci ; 4(6): 684-697, 2019 Oct.

Article en En | MEDLINE | ID: mdl-31709318

Palabras clave

AIM2, absence in melanoma 2; ANOVA, analysis of variance; ARCH, age-related clonal hematopoiesis; BMT, bone marrow transplant; CCL2, C-C motif chemokine ligand 2; CHIP, clonal hematopoiesis of indeterminate potential; GFP, green fluorescent protein; HSC, hematopoietic stem cell; HSPC, hematopoietic stem and progenitor cell; IFNGR1, interferon gamma receptor 1; IL, interleukin; JAK2, Janus kinase 2; JAK2V617F, mutant Janus kinase 2 (valine to phenylalanine at residue 617); JAK2WT, wild-type Janus kinase 2; LPS, lipopolysaccharide; LT-HSC, long-term hematopoietic stem cell; MI, myocardial infarction; MPN, myeloproliferative neoplasm; NET, neutrophil extracellular traps; STAT, signal transducer and activator of transcription; TAC, transverse aortic constriction surgery; clonal hematopoiesis; left ventricular hypertrophy; myocardial infarction

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