Immunogenicity and safety of vaccination against seasonal influenza vaccine in patients with psoriatic arthritis treated with secukinumab.
Vaccine
; 38(4): 847-851, 2020 01 22.
Article
en En
| MEDLINE
| ID: mdl-31767465
ABSTRACT
OBJECTIVE:
To assess the immunogenicity and safety of vaccination against seasonal influenza in psoriatic arthritis (PsA) patients treated with secukinumab versus healthy controls (HC).METHODS:
PsA patients administered secukinumab for ≥3â¯months and HC received the Sanofi Pasteur vaccine composed of 3 antigens (H3N3, H1N1, and B) and underwent clinical and laboratory assessments on the day of vaccination and 4-6â¯weeks later. Immunogenicity of the vaccine was evaluated by hemagglutination inhibition assay against those 3 antigens. Responders to each antigen were defined by a 4-fold increase in the antigen titer or by seroconversion in patients whose baseline level was <1/40.RESULTS:
Thirty-two consecutive PsA patients treated with secukinumab for ≥3â¯months comprised the study group, 10 of whom received concomitant conventional synthetic disease-modifying drugs, mostly methotrexate. There were 17 age- and gender-matched HC (median age 48.5â¯years, 6 females). The geometric mean titers of each antigen increased significantly in both groups. The number of responders in each group was similar for H3N2 and H1N1, and significantly higher for B/Brisbane in the PsA group. The proportion of patients with a seroprotective level (a titer >1/40) was high and similar in both groups. There was no correlation between the response rate and age, gender, or selected parameters of disease activity (tender/swollen joint counts, Leeds enthesitis index, physician and patient global assessment, psoriasis area severity index, and C-reactive protein). No disease exacerbation was observed following the vaccination. No serious adverse effects were observed in both groups during the study period.CONCLUSION:
Secukinumab treatment does not affect the humoral response to influenza vaccine of patients with PsA.Palabras clave
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Vacunas contra la Influenza
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Artritis Psoriásica
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Gripe Humana
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Anticuerpos Monoclonales Humanizados
Tipo de estudio:
Observational_studies
Límite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Vaccine
Año:
2020
Tipo del documento:
Article
País de afiliación:
Israel