G3BP1 inhibits RNA virus replication by positively regulating RIG-I-mediated cellular antiviral response.
Cell Death Dis
; 10(12): 946, 2019 12 11.
Article
en En
| MEDLINE
| ID: mdl-31827077
ABSTRACT
Retinoic acid-inducible gene I (RIG-I) is a pattern recognition receptor and is involved in the innate immune response against RNA viruses infection. Here, we demonstrate that the Ras-GTPase-activating protein SH3-domain-binding protein 1 (G3BP1) serves as a positive regulator of the RIG-I-mediated signaling pathway. G3BP1-deficient cells inhibited RNA virus-triggered induction of downstream antiviral genes. Furthermore, we found that G3BP1 inhibited the replication of Sendai virus and vesicular stomatitis virus, indicating a positive regulation of G3BP1 to cellular antiviral responses. Mechanistically, G3BP1 formed a complex with RNF125 and RIG-I, leading to decreased RNF125 via its auto-ubiquitination; thus, promoting expression of RIG-I. Overall, the results suggest a novel mechanism for G3BP1 in the positive regulation of antiviral signaling mediated by RIG-I.
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Infecciones por Virus ARN
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ADN Helicasas
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ARN Helicasas
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Ubiquitina-Proteína Ligasas
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Proteínas con Motivos de Reconocimiento de ARN
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Proteína 58 DEAD Box
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Proteínas de Unión a Poli-ADP-Ribosa
Límite:
Humans
Idioma:
En
Revista:
Cell Death Dis
Año:
2019
Tipo del documento:
Article
País de afiliación:
China