The protective effect of WKYMVm peptide on inflammatory osteolysis through regulating NF-&#954;B and CD9/gp130/STAT3 signalling pathway.

Hu, Junxian; Li, Xianghe; Chen, Yueqi; Han, Xinyun; Li, Li; Yang, Zhengwei; Duan, Lianli; Lu, Hongwei; He, Qingyi

The protective effect of WKYMVm peptide on inflammatory osteolysis through regulating NF-κB and CD9/gp130/STAT3 signalling pathway.

Hu, Junxian; Li, Xianghe; Chen, Yueqi; Han, Xinyun; Li, Li; Yang, Zhengwei; Duan, Lianli; Lu, Hongwei; He, Qingyi.

Afiliación

Hu J; Department of Orthopedics, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, China.
Li X; Guizhou Medical University, Guiyang, China.
Chen Y; Department of Orthopedics, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, China.
Han X; Department of Orthopedics, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, China.
Li L; Department of Orthopedics, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, China.
Yang Z; Department of Orthopedics, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, China.
Duan L; Department of Orthopedics, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, China.
Lu H; Department of Orthopedics, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, China.
He Q; Department of Orthopedics, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, China.

J Cell Mol Med ; 24(2): 1893-1905, 2020 01.

Article en En | MEDLINE | ID: mdl-31837208

Asunto(s)

Receptor gp130 de Citocinas/metabolismo; Inflamación/metabolismo; FN-kappa B/metabolismo; Oligopéptidos/farmacología; Osteólisis/metabolismo; Sustancias Protectoras/farmacología; Factor de Transcripción STAT3/metabolismo; Tetraspanina 29/metabolismo; Animales; Resorción Ósea/patología; Muerte Celular/efectos de los fármacos; Diferenciación Celular/efectos de los fármacos; Lipopolisacáridos/farmacología; Macrófagos/efectos de los fármacos; Macrófagos/metabolismo; Ratones; Ratones Endogámicos C57BL; Modelos Biológicos; Osteocalcina/metabolismo; Osteoclastos/efectos de los fármacos; Osteoclastos/metabolismo; Osteogénesis/efectos de los fármacos; Ligando RANK/farmacología; Células RAW 264.7; Especies Reactivas de Oxígeno/metabolismo; Transducción de Señal/efectos de los fármacos; Cráneo/diagnóstico por imagen; Cráneo/efectos de los fármacos; Cráneo/patología

Palabras clave

WKYMVm peptide; inflammatory osteolysis; lipopolysaccharide; osteoclastogenesis

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Texto completo: 1 Colección: 01-internacional Asunto principal: Oligopéptidos / Osteólisis / FN-kappa B / Sustancias Protectoras / Factor de Transcripción STAT3 / Receptor gp130 de Citocinas / Tetraspanina 29 / Inflamación Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Cell Mol Med Asunto de la revista: BIOLOGIA MOLECULAR Año: 2020 Tipo del documento: Article País de afiliación: China

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