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A 18ß-glycyrrhetinic acid conjugate with Vorinostat degrades HDAC3 and HDAC6 with improved antitumor effects.
Huang, Min; Xie, Xiaorui; Gong, Ping; Wei, Yunfei; Du, Heliang; Xu, Yuanbo; Xu, Qihao; Jing, Yongkui; Zhao, Linxiang.
Afiliación
  • Huang M; Key Laboratory of Structure-Based Drugs Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China.
  • Xie X; Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, 110016, China.
  • Gong P; Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, 110016, China.
  • Wei Y; Key Laboratory of Structure-Based Drugs Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China.
  • Du H; Key Laboratory of Structure-Based Drugs Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China.
  • Xu Y; Key Laboratory of Structure-Based Drugs Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China.
  • Xu Q; Key Laboratory of Structure-Based Drugs Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China.
  • Jing Y; Key Laboratory of Structure-Based Drugs Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China; Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, 110016, China. Electronic address: jingyk@syphu.edu.cn.
  • Zhao L; Key Laboratory of Structure-Based Drugs Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China. Electronic address: linxiang.zhao@vip.sina.com.
Eur J Med Chem ; 188: 111991, 2020 Feb 15.
Article en En | MEDLINE | ID: mdl-31883490
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Texto completo: 1 Colección: 01-internacional Asunto principal: Histona Desacetilasa 6 / Vorinostat / Ácido Glicirretínico / Antineoplásicos Límite: Animals / Humans / Male Idioma: En Revista: Eur J Med Chem Año: 2020 Tipo del documento: Article País de afiliación: China
Texto completo
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Texto completo: 1 Colección: 01-internacional Asunto principal: Histona Desacetilasa 6 / Vorinostat / Ácido Glicirretínico / Antineoplásicos Límite: Animals / Humans / Male Idioma: En Revista: Eur J Med Chem Año: 2020 Tipo del documento: Article País de afiliación: China