Anti-fibrotic effects of synthetic TGF-ß1 and Smad oligodeoxynucleotide on kidney fibrosis in vivo and in vitro through inhibition of both epithelial dedifferentiation and endothelial-mesenchymal transitions.

Gwon, Mi-Gyeong; An, Hyun-Jin; Kim, Jung-Yeon; Kim, Woon-Hae; Gu, Hyemin; Kim, Hyun-Ju; Leem, Jaechan; Jung, Hyun Jin; Park, Kwan-Kyu

Gwon, Mi-Gyeong; An, Hyun-Jin; Kim, Jung-Yeon; Kim, Woon-Hae; Gu, Hyemin; Kim, Hyun-Ju; Leem, Jaechan; Jung, Hyun Jin; Park, Kwan-Kyu.

Afiliación

Gwon MG; Department of Pathology, School of Medicine, Catholic University of Daegu, Daegu, Republic of Korea.
An HJ; Department of Pathology, School of Medicine, Catholic University of Daegu, Daegu, Republic of Korea.
Kim JY; Department of Immunology, School of Medicine, Catholic University of Daegu, Daegu, Republic of Korea.
Kim WH; Department of New Biology, DGIST, Daegu, Republic of Korea.
Gu H; Department of Pathology, School of Medicine, Catholic University of Daegu, Daegu, Republic of Korea.
Kim HJ; Department of Pathology, School of Medicine, Catholic University of Daegu, Daegu, Republic of Korea.
Leem J; Department of Immunology, School of Medicine, Catholic University of Daegu, Daegu, Republic of Korea.
Jung HJ; Department of Urology, School of Medicine, Catholic University of Daegu, Daegu, Republic of Korea.
Park KK; Department of Pathology, School of Medicine, Catholic University of Daegu, Daegu, Republic of Korea.

FASEB J ; 34(1): 333-349, 2020 01.

Article en En | MEDLINE | ID: mdl-31914629

Asunto(s)

Desdiferenciación Celular; Células Epiteliales/patología; Transición Epitelial-Mesenquimal; Fibrosis/prevención & control; Enfermedades Renales/prevención & control; Oligodesoxirribonucleótidos/farmacología; Proteínas Smad/genética; Factor de Crecimiento Transformador beta1/genética; Animales; Células Epiteliales/metabolismo; Fibrosis/genética; Fibrosis/patología; Técnicas In Vitro; Enfermedades Renales/genética; Enfermedades Renales/patología; Masculino; Ratones; Ratones Endogámicos C57BL; Obstrucción Ureteral/genética; Obstrucción Ureteral/patología; Obstrucción Ureteral/prevención & control

Palabras clave

EndoMT; TGFß1/Smad oligodeoxynucleotide; UUO; epithelial dedifferentiation; kidney fibrosis

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Texto completo: 1 Colección: 01-internacional Asunto principal: Oligodesoxirribonucleótidos / Fibrosis / Células Epiteliales / Proteínas Smad / Factor de Crecimiento Transformador beta1 / Desdiferenciación Celular / Transición Epitelial-Mesenquimal / Enfermedades Renales Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: FASEB J Asunto de la revista: BIOLOGIA / FISIOLOGIA Año: 2020 Tipo del documento: Article

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