Post-Essential Thrombocythemia Myelofibrosis and Multiple Isodicentric Y Chromosomes: A Unique Case among a Rare Association.
Cytogenet Genome Res
; 160(1): 18-21, 2020.
Article
en En
| MEDLINE
| ID: mdl-32008001
ABSTRACT
Multiple isodicentric Y chromosomes [idic(Y)] is a rare cytogenetic abnormality, most exclusively described in constitutional karyotypes. Only recently has this entity been reported in hematologic neoplasms such as myeloid disorders, albeit these cases remain very scarce. The possible involvement of increasing copies of potential proto-oncogenes located on the multiple idic(Y) led to consider one of them, CRLF2, as a target for kinase inhibitors. We report here, to our knowledge, the first case of multiple idic(Y) in a patient with myelofibrosis secondary to essential thrombocythemia. The patient received ruxolitinib therapy with initial good clinical response.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Aberraciones Cromosómicas Sexuales
/
Cromosomas Humanos Y
/
Mielofibrosis Primaria
/
Trombocitemia Esencial
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Límite:
Aged
/
Humans
/
Male
Idioma:
En
Revista:
Cytogenet Genome Res
Asunto de la revista:
GENETICA
Año:
2020
Tipo del documento:
Article