Cross-linked small-molecule capsules with excitation wavelength-dependent photoluminescence and high loading capacity: design, synthesis and application in imaging-guided drug delivery.
J Mater Chem B
; 8(13): 2719-2725, 2020 04 01.
Article
en En
| MEDLINE
| ID: mdl-32149293
ABSTRACT
The cross-linked small-molecule micelles (cSMs) have found applications in many fields but their low loading capacity and non-fluorescence property hindered their further development. Herein, water-soluble organic nanoparticles were applied as templates to "stretch" the hydrophobic core of cSMs and photo-cross-linking was employed to supply photoluminescence. The resulting cross-linked small-molecule capsules (cSCs) not only reserve the superior properties of cSMs of accurate monomer, easy functionalization and robust stability, but also achieve high drug loading capacity and excitation wavelength-dependent fluorescence, where the drug loading contents (DLCs) for various hydrophobic drugs were more than 30-fold higher than that of cSMs, and the maximum quantum yield could be as high as 12.0%. Featuring these superiorities, the cSCs hold promising potential in many fields and an example of doxorubicin-loaded cSCs (DOX@cSCs) for multichannel imaging-guided drug delivery is shown in this work.
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Doxorrubicina
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Sistemas de Liberación de Medicamentos
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Reactivos de Enlaces Cruzados
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Bibliotecas de Moléculas Pequeñas
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Imagen Óptica
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Mediciones Luminiscentes
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Antibióticos Antineoplásicos
Límite:
Humans
Idioma:
En
Revista:
J Mater Chem B
Año:
2020
Tipo del documento:
Article
País de afiliación:
China