Novel Chitosan Derivatives with Reversible Cationization and Hydrophobicization for Tumor Cytoplasm-Specific Burst Co-delivery of siRNA and Chemotherapeutics.

Yin, Tingjie; Liu, Yanqi; Yang, Mengnan; Wang, Lei; Zhou, Jianping; Huo, Meirong

Yin, Tingjie; Liu, Yanqi; Yang, Mengnan; Wang, Lei; Zhou, Jianping; Huo, Meirong.

Afiliación

Yin T; State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, China.
Liu Y; State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, China.
Yang M; State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, China.
Wang L; Department of Pharmaceutics, Guizhou Medical University, Huaxi university town, Guian new district 550025 Guizhou, People's Republic of China.
Zhou J; State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, China.
Huo M; State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, China.

ACS Appl Mater Interfaces ; 12(13): 14770-14783, 2020 Apr 01.

Article en En | MEDLINE | ID: mdl-32149497

Asunto(s)

Antineoplásicos Fitogénicos/metabolismo; Quitosano/química; ARN Interferente Pequeño/metabolismo; Células A549; Animales; Antineoplásicos Fitogénicos/química; Antineoplásicos Fitogénicos/uso terapéutico; Cationes/química; Citoplasma/metabolismo; Portadores de Fármacos/química; Femenino; Glutatión/química; Humanos; Ácido Hialurónico/química; Ratones; Ratones Desnudos; Micelas; Neoplasias/tratamiento farmacológico; Neoplasias/patología; Paclitaxel/química; Paclitaxel/metabolismo; Tamaño de la Partícula; Polietileneimina/química; ARN Interferente Pequeño/uso terapéutico; Ensayos Antitumor por Modelo de Xenoinjerto

Palabras clave

chitosan amphiphile; co-delivery and co-burst release; maximized synergistic potency; reversible cationization and hydrophobicization; siRNA and chemotherapeutics

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Texto completo: 1 Colección: 01-internacional Asunto principal: ARN Interferente Pequeño / Quitosano / Antineoplásicos Fitogénicos Límite: Animals / Female / Humans Idioma: En Revista: ACS Appl Mater Interfaces Asunto de la revista: BIOTECNOLOGIA / ENGENHARIA BIOMEDICA Año: 2020 Tipo del documento: Article País de afiliación: China

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