Queuine Micronutrient Deficiency Promotes Warburg Metabolism and Reversal of the Mitochondrial ATP Synthase in Hela Cells.

Hayes, Patti; Fergus, Claire; Ghanim, Magda; Cirzi, Cansu; Burtnyak, Lyubomyr; McGrenaghan, Callum J; Tuorto, Francesca; Nolan, Derek P; Kelly, Vincent P

Hayes, Patti; Fergus, Claire; Ghanim, Magda; Cirzi, Cansu; Burtnyak, Lyubomyr; McGrenaghan, Callum J; Tuorto, Francesca; Nolan, Derek P; Kelly, Vincent P.

Afiliación

Hayes P; School of Biochemistry & Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, 2 Dublin, Ireland.
Fergus C; School of Biochemistry & Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, 2 Dublin, Ireland.
Ghanim M; School of Biochemistry & Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, 2 Dublin, Ireland.
Cirzi C; Division of Epigenetics, German Cancer Research Center (DKFZ), DKFZ-ZMBH Alliance, 69120 Heidelberg, Germany.
Burtnyak L; Faculty of Biosciences, University of Heidelberg, 69120 Heidelberg, Germany.
McGrenaghan CJ; School of Biochemistry & Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, 2 Dublin, Ireland.
Tuorto F; School of Biochemistry & Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, 2 Dublin, Ireland.
Nolan DP; Division of Epigenetics, German Cancer Research Center (DKFZ), DKFZ-ZMBH Alliance, 69120 Heidelberg, Germany.
Kelly VP; Center for Molecular Biology of Heidelberg University (ZMBH), DKFZ-ZMBH Alliance, 69120 Heidelberg, Germany.

Nutrients ; 12(3)2020 03 24.

Article en En | MEDLINE | ID: mdl-32213952

Asunto(s)

Metabolismo Energético; Guanina/análogos & derivados; Micronutrientes/deficiencia; Mitocondrias/metabolismo; ATPasas de Translocación de Protón Mitocondriales/metabolismo; Activación Enzimática; Glutamina/metabolismo; Glucólisis; Guanina/metabolismo; Células HeLa; Humanos; Mitocondrias/ultraestructura; Modelos Biológicos; ARN de Transferencia/genética; ARN de Transferencia/metabolismo

Palabras clave

Queuine; RNA modification; Warburg metabolism; aerobic glycolysis; microbiome; micronutrient; queuosine

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Texto completo: 1 Colección: 01-internacional Asunto principal: Micronutrientes / ATPasas de Translocación de Protón Mitocondriales / Metabolismo Energético / Guanina / Mitocondrias Límite: Humans Idioma: En Revista: Nutrients Año: 2020 Tipo del documento: Article País de afiliación: Irlanda

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