Life, death, and autophagy in cancer: NF-κB turns up everywhere.
Cell Death Dis
; 11(3): 210, 2020 03 30.
Article
en En
| MEDLINE
| ID: mdl-32231206
ABSTRACT
Escaping programmed cell death is a hallmark of cancer. NF-κB transcription factors are key regulator of cell survival and aberrant NF-κB signaling has been involved in the pathogenesis of most human malignancies. Although NF-κB is best known for its antiapoptotic role, other processes regulating the life/death balance, such as autophagy and necroptosis, seem to network with NF-κB. This review discusses how the reciprocal regulation of NF-κB, autophagy and programmed cell death affect cancer development and progression.
Texto completo:
1
Colección:
01-internacional
Asunto principal:
FN-kappa B
/
Neoplasias
Límite:
Humans
Idioma:
En
Revista:
Cell Death Dis
Año:
2020
Tipo del documento:
Article
País de afiliación:
Italia