Transcription Dynamics Regulate Poly(A) Tails and Expression of the RNA Degradation Machinery to Balance mRNA Levels.

Slobodin, Boris; Bahat, Anat; Sehrawat, Urmila; Becker-Herman, Shirly; Zuckerman, Binyamin; Weiss, Amanda N; Han, Ruiqi; Elkon, Ran; Agami, Reuven; Ulitsky, Igor; Shachar, Idit; Dikstein, Rivka

Slobodin, Boris; Bahat, Anat; Sehrawat, Urmila; Becker-Herman, Shirly; Zuckerman, Binyamin; Weiss, Amanda N; Han, Ruiqi; Elkon, Ran; Agami, Reuven; Ulitsky, Igor; Shachar, Idit; Dikstein, Rivka.

Afiliación

Slobodin B; Department of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot 76100, Israel. Electronic address: boris.slobodin@gmail.com.
Bahat A; Department of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot 76100, Israel.
Sehrawat U; Department of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot 76100, Israel.
Becker-Herman S; Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel.
Zuckerman B; Department of Biological Regulation, The Weizmann Institute of Science, Rehovot 76100, Israel.
Weiss AN; Department of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot 76100, Israel.
Han R; Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands.
Elkon R; Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.
Agami R; Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands.
Ulitsky I; Department of Biological Regulation, The Weizmann Institute of Science, Rehovot 76100, Israel.
Shachar I; Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel.
Dikstein R; Department of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot 76100, Israel. Electronic address: rivka.dikstein@weizmann.ac.il.

Mol Cell ; 78(3): 434-444.e5, 2020 05 07.

Article en En | MEDLINE | ID: mdl-32294471

Asunto(s)

Poli A/genética; ARN Mensajero/metabolismo; Transcripción Genética; Adenosina/análogos & derivados; Animales; Linfocitos B/fisiología; Células Cultivadas; Femenino; Regulación de la Expresión Génica; Humanos; Sitios Internos de Entrada al Ribosoma; Células MCF-7; Ratones Endogámicos C57BL; Miembro 2 del Grupo A de la Subfamilia 4 de Receptores Nucleares/genética; Miembro 2 del Grupo A de la Subfamilia 4 de Receptores Nucleares/metabolismo; Poli A/metabolismo; ARN Polimerasa II/genética; ARN Polimerasa II/metabolismo; Estabilidad del ARN; ARN Mensajero/genética; Receptores CCR4/genética; Receptores CCR4/metabolismo

Palabras clave

CCR4-Not complex; IRES; RNA polymerase II; gene expression buffering; m(6)A; m6A methyltransferase complex; mRNA buffering; mRNA degradation; poly(A) tails; transcription

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Texto completo: 1 Colección: 01-internacional Asunto principal: Poli A / Transcripción Genética / ARN Mensajero Límite: Animals / Female / Humans Idioma: En Revista: Mol Cell Asunto de la revista: BIOLOGIA MOLECULAR Año: 2020 Tipo del documento: Article

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