Radiation-Induced Hyalinizing Clear Cell Carcinoma of the Orbit.
Ophthalmic Plast Reconstr Surg
; 37(1): e21-e23, 2021.
Article
en En
| MEDLINE
| ID: mdl-32427738
ABSTRACT
Radiation-induced malignancy is rare, occurring in approximately 0.4%-1.0% of patients receiving external beam radiation therapy. Sarcomas and squamous cell carcinomas are among the most common types of cancers to occur. A 74-year-old woman presented with redness and swelling in the right periorbital region. She had history of multiple recurrent ameloblastoma of the right maxilla, invading the right orbital floor status post 4 surgical resections and 66 Gray external beam radiotherapy 5 years prior. MRI showed a poorly circumscribed mass involving the inferior and lateral orbit. Orbital biopsy revealed clear cell carcinoma with hyalinizing sclerosis and Ewing sarcoma breakpoint region 1 gene arrangement. Due to the extent of orbital disease and presence of perineural invasion, she underwent orbital exenteration. Hyalinizing clear cell carcinoma, a rare cancer, has not been reported to occur in the orbit following radiation. This case highlights the importance of lifetime monitoring in patients who have undergone radiation therapy.
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Enfermedades Orbitales
/
Neoplasias Orbitales
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Carcinoma de Células Escamosas
Límite:
Aged
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Female
/
Humans
Idioma:
En
Revista:
Ophthalmic Plast Reconstr Surg
Asunto de la revista:
OFTALMOLOGIA
Año:
2021
Tipo del documento:
Article