Heterologous reconstitution of the biosynthesis pathway for 4-demethyl-premithramycinone, the aglycon of antitumor polyketide mithramycin.

Zabala, Daniel; Song, Lijiang; Dashti, Yousef; Challis, Gregory L; Salas, José A; Méndez, Carmen

Zabala, Daniel; Song, Lijiang; Dashti, Yousef; Challis, Gregory L; Salas, José A; Méndez, Carmen.

Afiliación

Zabala D; Departamento de Biología Funcional e Instituto Universitario de Oncología del Principado de Asturias (I.U.O.P.A), University of Oviedo, Oviedo, Spain.
Song L; Department of Chemistry, University of Warwick, Coventry, CV4 7AL, UK.
Dashti Y; Department of Chemistry, University of Warwick, Coventry, CV4 7AL, UK.
Challis GL; Department of Chemistry, University of Warwick, Coventry, CV4 7AL, UK.
Salas JA; Department of Chemistry, University of Warwick, Coventry, CV4 7AL, UK.
Méndez C; Warwick Integrative Synthetic Biology Centre, University of Warwick, Coventry, CV4 7AL, UK.

Microb Cell Fact ; 19(1): 111, 2020 May 24.

Article en En | MEDLINE | ID: mdl-32448325

Asunto(s)

Antibióticos Antineoplásicos/biosíntesis; Plicamicina/biosíntesis; Policétidos/metabolismo; Streptomyces; Proteínas Bacterianas/genética; Proteínas Bacterianas/metabolismo; Streptomyces/genética; Streptomyces/metabolismo

Palabras clave

Acyl-CoA ligase; Aureolic acid; Cyclase; Mithramycin; Polyketide synthase; Premithramycinone; Streptomyces argillaceus

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Texto completo: 1 Colección: 01-internacional Asunto principal: Streptomyces / Plicamicina / Policétidos / Antibióticos Antineoplásicos Idioma: En Revista: Microb Cell Fact Asunto de la revista: BIOTECNOLOGIA / MICROBIOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: España

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