Deep Brain Stimulation in the Nucleus Accumbens for Binge Eating Disorder: a Study in Rats.
Obes Surg
; 30(10): 4145-4148, 2020 10.
Article
en En
| MEDLINE
| ID: mdl-32451916
ABSTRACT
Binge eating disorder (BED), with its compulsive and addictive components, may often underlie weight regain after gastrointestinal bariatric surgeries. BED is therefore considered an exclusion criterion for these surgeries. Anecdotal reports suggest that deep brain stimulation (DBS) is an effective treatment for addictive disorders with, similar to BED, pathological changes in cerebral reward circuitry. We therefore assessed effect of DBS of the nucleus accumbens (NAC) in a rat model of BED. Twenty-one male obesity prone Wistar rats with DBS electrodes placed in NAC subregions were subjected to a binge eating protocol. Binge eating was significantly reduced with DBS during (NAC core) or before (NAC lateral shell) the binge. These outcomes provide a base to further explore the potential of DBS in the treatment of BED.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Obesidad Mórbida
/
Estimulación Encefálica Profunda
/
Trastorno por Atracón
Tipo de estudio:
Guideline
/
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Obes Surg
Asunto de la revista:
METABOLISMO
Año:
2020
Tipo del documento:
Article
País de afiliación:
Países Bajos