Novel Forms of Immunomodulation for Cancer Therapy.
Trends Cancer
; 6(6): 518-532, 2020 06.
Article
en En
| MEDLINE
| ID: mdl-32460005
ABSTRACT
In recent years immunotherapy has provided new hope for cancer patients. However, some patients eventually relapse. Immunological responses are thought to underlie the long-term effects of conventional or targeted therapies. Whether this influence emerges from direct effects on cancer cells through immunogenic cell death (ICD) or by modulating the immune environment requires further clarification. ICD-related molecular mechanisms are also shared by cell-intrinsic defense responses that combat foreign intrusions. Indeed, we could potentially mimic and harness these processes to improve cancer immunogenicity. In addition, the microbiome is materializing as a missing factor in the cancer-immune therapy axis. The emerging idea of manipulating the gut microbiota to improve responses to anticancer therapy is becoming increasingly popular, but further clinical authentication is needed.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Protocolos de Quimioterapia Combinada Antineoplásica
/
Disbiosis
/
Microbioma Gastrointestinal
/
Inmunoterapia
/
Neoplasias
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Trends Cancer
Año:
2020
Tipo del documento:
Article