Cytokine clusters as potential diagnostic markers of disease activity and renal involvement in systemic lupus erythematosus.
J Int Med Res
; 48(6): 300060520926882, 2020 Jun.
Article
en En
| MEDLINE
| ID: mdl-32489126
ABSTRACT
OBJECTIVE:
To describe interactions among cytokines and to identify subgroups of systemic lupus erythematosus (SLE) patients based on cytokine levels using principal component analysis and cluster analysis.METHODS:
Levels of 12 cytokines were measured using sensitive multiplex bead assays and associations with SLE features including disease activity and renal involvement were assessed.RESULTS:
In a group of 203 SLE patients, strong correlations were observed between interleukin (IL)6 and interferon (IFN)γ levels (r = 0.624), IL17 and IFNγ levels (r = 0.768), and macrophage inflammatory protein (MIP)1α and MIP1ß levels (r = 0.675). Cluster analysis revealed two distinct patient groups characterized by high levels of IL8, MIP1α, and MIP1ß (group 1) or of IL2, IL6, IL10, IL12, IFNγ, and tumor necrosis factor α (group 2). Active disease was more common in group 1 (49/88, 55.7%) than in group 2 (40/115, 34.8%). More patients in group 2 had renal involvement (42/115, 36.5%) than in group 1 (22/88, 25%).CONCLUSIONS:
Assessment of cytokine profiles can identify distinct SLE patient subgroups and aid in understanding clinical heterogeneity and immunological phenotypes.Palabras clave
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Nefritis Lúpica
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Citocinas
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Lupus Eritematoso Sistémico
Tipo de estudio:
Diagnostic_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Adolescent
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Adult
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Aged
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Child
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
J Int Med Res
Año:
2020
Tipo del documento:
Article