Chronic-plus-binge alcohol intake induces production of proinflammatory mtDNA-enriched extracellular vesicles and steatohepatitis via ASK1/p38MAPK&#945;-dependent mechanisms.

Ma, Jing; Cao, Haixia; Rodrigues, Robim M; Xu, Mingjiang; Ren, Tianyi; He, Yong; Hwang, Seonghwan; Feng, Dechun; Ren, Ruixue; Yang, Peixin; Liangpunsakul, Suthat; Sun, Jian; Gao, Bin

Chronic-plus-binge alcohol intake induces production of proinflammatory mtDNA-enriched extracellular vesicles and steatohepatitis via ASK1/p38MAPKα-dependent mechanisms.

Ma, Jing; Cao, Haixia; Rodrigues, Robim M; Xu, Mingjiang; Ren, Tianyi; He, Yong; Hwang, Seonghwan; Feng, Dechun; Ren, Ruixue; Yang, Peixin; Liangpunsakul, Suthat; Sun, Jian; Gao, Bin.

Afiliación

Ma J; State Key Laboratory of Organ Failure Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Cao H; Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, Maryland, USA.
Rodrigues RM; Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, Maryland, USA.
Xu M; Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, Maryland, USA.
Ren T; Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, Maryland, USA.
He Y; Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, Maryland, USA.
Hwang S; Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, Maryland, USA.
Feng D; Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, Maryland, USA.
Ren R; Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, Maryland, USA.
Yang P; Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, Maryland, USA.
Liangpunsakul S; Department of Obstetrics and Gynecology Science, University of Maryland, School of Medicine, Baltimore, Maryland, USA.
Sun J; Division of Gastroenterology and Hepatology, Department of Medicine, and.
Gao B; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA.

JCI Insight ; 5(14)2020 07 23.

Article en En | MEDLINE | ID: mdl-32544093

Asunto(s)

Vesículas Extracelulares/genética; Hígado Graso Alcohólico/genética; Inflamación/genética; MAP Quinasa Quinasa Quinasa 5/genética; Proteínas Quinasas p38 Activadas por Mitógenos/genética; Alcoholismo/complicaciones; Alcoholismo/genética; Alcoholismo/patología; Alcoholes/toxicidad; Animales; Consumo Excesivo de Bebidas Alcohólicas/complicaciones; Consumo Excesivo de Bebidas Alcohólicas/genética; Consumo Excesivo de Bebidas Alcohólicas/patología; ADN Mitocondrial/genética; Modelos Animales de Enfermedad; Vesículas Extracelulares/efectos de los fármacos; Hígado Graso Alcohólico/etiología; Hígado Graso Alcohólico/patología; Hepatocitos/efectos de los fármacos; Humanos; Inflamación/etiología; Inflamación/patología; Hígado/efectos de los fármacos; Metaloproteinasa 14 de la Matriz/genética; Metalotioneína/genética; Ratones; Transducción de Señal/efectos de los fármacos

Palabras clave

Hepatology; Toxicology

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Texto completo: 1 Colección: 01-internacional Asunto principal: MAP Quinasa Quinasa Quinasa 5 / Proteínas Quinasas p38 Activadas por Mitógenos / Hígado Graso Alcohólico / Vesículas Extracelulares / Inflamación Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Animals / Humans Idioma: En Revista: JCI Insight Año: 2020 Tipo del documento: Article País de afiliación: China

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