Ionizing radiation induces BH<sub>4</sub> deficiency by downregulating GTP-cyclohydrolase 1, a novel target for preventing and treating radiation enteritis.

Yan, Tao; Zhang, Tian; Mu, Wei; Qi, Yuhong; Guo, Shun; Hu, Na; Zhao, Weihe; Zhang, Song; Wang, Qinhui; Shi, Lei; Liu, Linna

Ionizing radiation induces BH₄ deficiency by downregulating GTP-cyclohydrolase 1, a novel target for preventing and treating radiation enteritis.

Yan, Tao; Zhang, Tian; Mu, Wei; Qi, Yuhong; Guo, Shun; Hu, Na; Zhao, Weihe; Zhang, Song; Wang, Qinhui; Shi, Lei; Liu, Linna.

Afiliación

Yan T; Department of Pharmacy, The Second Affiliated Hospital of Air Force Medical University, Xi'an, PR China.
Zhang T; Department of Pharmacy, The Second Affiliated Hospital of Air Force Medical University, Xi'an, PR China.
Mu W; Department of Pharmacy, The Second Affiliated Hospital of Air Force Medical University, Xi'an, PR China.
Qi Y; Department of Radiotherapy, The Second Affiliated Hospital of Air Force Medical University, Xi'an, PR China.
Guo S; Department of Pharmacy, The Second Affiliated Hospital of Air Force Medical University, Xi'an, PR China.
Hu N; Department of Pharmacy, The Second Affiliated Hospital of Air Force Medical University, Xi'an, PR China.
Zhao W; Department of Radiotherapy, The Second Affiliated Hospital of Air Force Medical University, Xi'an, PR China.
Zhang S; Department of Pharmacy, The Second Affiliated Hospital of Air Force Medical University, Xi'an, PR China.
Wang Q; Department of Pharmacy, The Second Affiliated Hospital of Air Force Medical University, Xi'an, PR China.
Shi L; Department of Pharmacy, The Second Affiliated Hospital of Air Force Medical University, Xi'an, PR China. Electronic address: shilei1860@126.com.
Liu L; Department of Pharmacy, The Second Affiliated Hospital of Air Force Medical University, Xi'an, PR China. Electronic address: liulinna@fmmu.edu.cn.

Biochem Pharmacol ; 180: 114102, 2020 10.

Article en En | MEDLINE | ID: mdl-32562786

Asunto(s)

Enteritis/prevención & control; GTP Ciclohidrolasa/genética; Intestinos/irrigación sanguínea; Fenilcetonurias/sangre; Traumatismos por Radiación/prevención & control; Radioterapia/efectos adversos; Anciano; Anciano de 80 o más Años; Animales; Biopterinas/análogos & derivados; Biopterinas/farmacología; Regulación hacia Abajo; Endotelio Vascular/efectos de los fármacos; Endotelio Vascular/efectos de la radiación; Enteritis/sangre; Enteritis/genética; Enteritis/patología; Femenino; GTP Ciclohidrolasa/antagonistas & inhibidores; Células Endoteliales de la Vena Umbilical Humana; Humanos; Masculino; Arterias Mesentéricas/efectos de los fármacos; Arterias Mesentéricas/efectos de la radiación; Persona de Mediana Edad; Óxido Nítrico Sintasa de Tipo III/metabolismo; Fenilcetonurias/etiología; Traumatismos por Radiación/sangre; Traumatismos por Radiación/genética; Traumatismos por Radiación/patología; Traumatismos Experimentales por Radiación/sangre; Traumatismos Experimentales por Radiación/genética; Traumatismos Experimentales por Radiación/prevención & control; Ratas; Ratas Sprague-Dawley; Vasodilatación/efectos de los fármacos; Vasodilatación/efectos de la radiación

Palabras clave

Endothelial nitric oxide synthase; GTP-cyclohydrolase 1; Nitric oxide; Radiation enteritis; Tetrahydrobiopterin

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Texto completo: 1 Colección: 01-internacional Asunto principal: Fenilcetonurias / Traumatismos por Radiación / Radioterapia / Enteritis / GTP Ciclohidrolasa / Intestinos Tipo de estudio: Etiology_studies Límite: Aged80 Idioma: En Revista: Biochem Pharmacol Año: 2020 Tipo del documento: Article

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