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Anti-Interleukin-10 Unleashes Transcriptional Response to Leishmanial Antigens in Visceral Leishmaniasis Patients.
Singh, Om Prakash; Syn, Genevieve; Nylén, Susanne; Engwerda, Christian; Sacks, David; Wilson, Mary E; Kumar, Rajiv; Chakravarty, Jaya; Sundar, Shyam; Blackwell, Jenefer M; Fakiola, Michaela.
Afiliación
  • Singh OP; Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.
  • Syn G; Department of Biochemistry, Institute of Science, Banaras Hindu University, Varanasi, Uttar Pradesh, India.
  • Nylén S; Telethon Kids Institute, The University of Western Australia, Nedlands, Western Australia, Australia.
  • Engwerda C; Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.
  • Sacks D; QIMR Berghofer Medical Research Institute, Brisbane, Australia.
  • Wilson ME; Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes for Health, Bethesda, Maryland, USA.
  • Kumar R; Department of Microbiology and Immunology, University of Iowa, Iowa City, Iowa, USA.
  • Chakravarty J; Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.
  • Sundar S; Centre for Experimental Medicine and Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.
  • Blackwell JM; Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.
  • Fakiola M; Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.
J Infect Dis ; 223(3): 517-521, 2021 02 13.
Article en En | MEDLINE | ID: mdl-32614452
ABSTRACT
Visceral leishmaniasis (VL; Leishmania donovani) cases produce interferon-γ and tumor necrosis factor in response to soluble leishmanial antigen (SLA) in whole-blood assays. Using transcriptional profiling, we demonstrate the impact of interleukin-10 (IL-10), a cytokine implicated in VL, on this response. SLA stimulation identified 28 differentially expressed genes (DEGs), 17/28 in a single network with TNF as hub. SLA plus anti-IL-10 produced 454 DEGs, 292 in a single network with TNF, IFNG, NFKBIA, IL6, and IL1B as hubs in concert with a remarkable chemokine/cytokine storm. Our data demonstrate the singular effect of IL-10 as a potent immune modulator in VL.
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Texto completo: 1 Colección: 01-internacional Asunto principal: Anticuerpos Antiprotozoarios / Interleucina-10 / Leishmaniasis Visceral / Antígenos de Protozoos Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: J Infect Dis Año: 2021 Tipo del documento: Article País de afiliación: India
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Texto completo: 1 Colección: 01-internacional Asunto principal: Anticuerpos Antiprotozoarios / Interleucina-10 / Leishmaniasis Visceral / Antígenos de Protozoos Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: J Infect Dis Año: 2021 Tipo del documento: Article País de afiliación: India