Brief stress impairs recognition memory through amygdalar activation in animals with medial prefrontal cortex lesions.
Neurosci Lett
; 735: 135245, 2020 09 14.
Article
en En
| MEDLINE
| ID: mdl-32652210
ABSTRACT
The medial prefrontal cortex (mPFC) is thought to exert inhibitory control over stress-induced activation of the amygdala and neurocognitive effects. As evidence to support this, we examined how exposure to either a brief or prolonged stress affected on amygdalar c-Fos levels and recognition memory of animals with mPFC chemical lesions. mPFC-lesioned and sham-operated animals were subjected to either a brief 20-min restraint+20 tailshocks or a prolonged 60-min restraint+60 tailshocks. Post-stress performances in the object recognition memory and c-Fos immunoreactivity in the amygdala were then assessed. In sham-operated animals, the object recognition memory was reliably impaired following the prolonged, but not following the brief stress exposure. On the other hand, in mPFC-lesioned animals, the brief stress significantly impaired recognition memory and enhanced c-Fos expression in the amygdala. Present findings of loss of mPFC activity exacerbating stress effects provide causal evidence that the mPFC exerts inhibitory control on stress.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Estrés Psicológico
/
Corteza Prefrontal
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Reconocimiento en Psicología
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Amígdala del Cerebelo
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Memoria
Límite:
Animals
Idioma:
En
Revista:
Neurosci Lett
Año:
2020
Tipo del documento:
Article