Potential therapeutic effect of targeting glycogen synthase kinase 3ß in esophageal squamous cell carcinoma.

Bolidong, Dilireba; Domoto, Takahiro; Uehara, Masahiro; Sabit, Hemragul; Okumura, Tomoyuki; Endo, Yoshio; Nakada, Mitsutoshi; Ninomiya, Itasu; Miyashita, Tomoharu; Wong, Richard W; Minamoto, Toshinari

Bolidong, Dilireba; Domoto, Takahiro; Uehara, Masahiro; Sabit, Hemragul; Okumura, Tomoyuki; Endo, Yoshio; Nakada, Mitsutoshi; Ninomiya, Itasu; Miyashita, Tomoharu; Wong, Richard W; Minamoto, Toshinari.

Afiliación

Bolidong D; Division of Translational and Clinical Oncology, Cancer Research Institute, Kanazawa University, 13-1 Takara-machi, Kanazawa, 920-0934, Japan.
Domoto T; Division of Translational and Clinical Oncology, Cancer Research Institute, Kanazawa University, 13-1 Takara-machi, Kanazawa, 920-0934, Japan.
Uehara M; Division of Translational and Clinical Oncology, Cancer Research Institute, Kanazawa University, 13-1 Takara-machi, Kanazawa, 920-0934, Japan.
Sabit H; Department of Neurosurgery, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan.
Okumura T; Department of Surgery and Science, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan.
Endo Y; Central Research Resource Branch, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.
Nakada M; Department of Neurosurgery, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan.
Ninomiya I; Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan.
Miyashita T; Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan.
Wong RW; Department of Surgical Oncology, Kanazawa Medical University Hospital, Ishikawa, Japan.
Minamoto T; WPI Nano Life Science Institute, Kanazawa University, Kanazawa, Japan.

Sci Rep ; 10(1): 11807, 2020 07 16.

Article en En | MEDLINE | ID: mdl-32678196

Asunto(s)

Antineoplásicos/farmacología; Neoplasias Esofágicas/metabolismo; Carcinoma de Células Escamosas de Esófago/metabolismo; Glucógeno Sintasa Quinasa 3 beta/antagonistas & inhibidores; Adulto; Anciano; Animales; Antineoplásicos/uso terapéutico; Apoptosis/efectos de los fármacos; Biomarcadores de Tumor; Línea Celular Tumoral; Proliferación Celular/efectos de los fármacos; Supervivencia Celular/efectos de los fármacos; Modelos Animales de Enfermedad; Neoplasias Esofágicas/tratamiento farmacológico; Neoplasias Esofágicas/genética; Neoplasias Esofágicas/patología; Carcinoma de Células Escamosas de Esófago/tratamiento farmacológico; Carcinoma de Células Escamosas de Esófago/genética; Carcinoma de Células Escamosas de Esófago/patología; Femenino; Expresión Génica; Glucógeno/metabolismo; Glucógeno Sintasa Quinasa 3 beta/genética; Glucógeno Sintasa Quinasa 3 beta/metabolismo; Humanos; Masculino; Ratones; Persona de Mediana Edad; Terapia Molecular Dirigida; Metástasis de la Neoplasia; Estadificación de Neoplasias; Fosforilación; Ensayos Antitumor por Modelo de Xenoinjerto

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Texto completo: 1 Colección: 01-internacional Asunto principal: Neoplasias Esofágicas / Glucógeno Sintasa Quinasa 3 beta / Carcinoma de Células Escamosas de Esófago / Antineoplásicos Límite: Adult / Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Sci Rep Año: 2020 Tipo del documento: Article País de afiliación: Japón

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