Treatment-recalcitrant laryngeal sarcoidosis responsive to sirolimus.
BMJ Case Rep
; 13(8)2020 Aug 26.
Article
en En
| MEDLINE
| ID: mdl-32847880
ABSTRACT
A 15-year-old girl presented with gradual-onset dysphonia and dysphagia. Laryngoscopy revealed significant supraglottic airway obstruction with swelling of both the epiglottis and arytenoids. After emergency tracheostomy, biopsy of the epiglottis revealed lymphoid hyperplasia with focal non-necrotising granulomata, leading to a presumed diagnosis of laryngeal sarcoidosis. Treatment with prednisolone and methotrexate produced minimal clinical improvement. A switch to sirolimus was followed by significant reduction in the laryngeal swelling, allowing decannulation of the tracheostomy. Treatment with sirolimus should be considered as a steroid sparing agent in laryngeal sarcoidosis, particularly in the presence of lymphoid hyperplasia on biopsy.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Sarcoidosis
/
Enfermedades de la Laringe
/
Sirolimus
Límite:
Adolescent
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Female
/
Humans
Idioma:
En
Revista:
BMJ Case Rep
Año:
2020
Tipo del documento:
Article
País de afiliación:
Irlanda