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Human pediatric B-cell acute lymphoblastic leukemias can be classified as B-1 or B-2-like based on a minimal transcriptional signature.
Fitch, Briana; Roy, Ritu; Geng, Huimin; Montecino-Rodriguez, Encarnacion; Bengtsson, Henrik; Gaillard, Coline; Hiam, Kamir; Casero, David; Olshen, Adam B; Dorshkind, Kenneth; Kogan, Scott C.
Afiliación
  • Fitch B; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA.
  • Roy R; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA; Computational Biology and Informatics, University of California, San Francisco, San Francisco, CA.
  • Geng H; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA.
  • Montecino-Rodriguez E; Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA.
  • Bengtsson H; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA.
  • Gaillard C; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA.
  • Hiam K; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA.
  • Casero D; Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA.
  • Olshen AB; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA; Computational Biology and Informatics, University of California, San Francisco, San Francisco, CA; Department of Epidemiology and Biostatistics, University of California, San Francisco, San F
  • Dorshkind K; Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA.
  • Kogan SC; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA. Electronic address: Scott.Kogan@ucsf.edu.
Exp Hematol ; 90: 65-71.e1, 2020 10.
Article en En | MEDLINE | ID: mdl-32946981
ABSTRACT
The finding that transformed mouse B-1 and B-2 progenitors give rise to B-cell acute lymphoblastic leukemias (B-ALLs) with varied aggressiveness suggests that B-cell lineage might also be a factor in the initiation and progression of pediatric B-ALLs in humans. If this is the case, we hypothesized that human pediatric B-ALLs would share gene expression patterns with mouse B-1 or B-2 progenitors. We tested this premise by deriving a distinct 30-gene B-1 and B-2 progenitor signature that was applied to a microarray data set of human pediatric ALLs. Cluster analysis revealed that CRLF2, E2A-PBX1, ERG, and ETV6-RUNX1 leukemias were B-1-like, whereas BCR-ABL1, hyperdiploid, and MLL leukemias were B-2-like. Examination of the 30-gene signature in two independent data sets of pediatric ALLs supported this result. Our data suggest that common genetic subtypes of human ALL have their origin in the B-1 or B-2 lineage.
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Texto completo: 1 Colección: 01-internacional Asunto principal: Regulación Leucémica de la Expresión Génica / Perfilación de la Expresión Génica / Leucemia-Linfoma Linfoblástico de Células T Precursoras / Transcriptoma / Proteínas de Neoplasias Límite: Animals / Child / Humans Idioma: En Revista: Exp Hematol Año: 2020 Tipo del documento: Article País de afiliación: Canadá
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Texto completo: 1 Colección: 01-internacional Asunto principal: Regulación Leucémica de la Expresión Génica / Perfilación de la Expresión Génica / Leucemia-Linfoma Linfoblástico de Células T Precursoras / Transcriptoma / Proteínas de Neoplasias Límite: Animals / Child / Humans Idioma: En Revista: Exp Hematol Año: 2020 Tipo del documento: Article País de afiliación: Canadá