CRISPR-Cas9 Genome-Wide Knockout Screen Identifies Mechanism of Selective Activity of Dehydrofalcarinol in Mesenchymal Stem-like Triple-Negative Breast Cancer Cells.

Grant, Corena V; Cai, Shengxin; Risinger, April L; Liang, Huiyun; O'Keefe, Barry R; Doench, John G; Cichewicz, Robert H; Mooberry, Susan L

Grant, Corena V; Cai, Shengxin; Risinger, April L; Liang, Huiyun; O'Keefe, Barry R; Doench, John G; Cichewicz, Robert H; Mooberry, Susan L.

Afiliación

Cai S; Natural Products Discovery Group, Institute for Natural Products Applications and Research Technologies, Department of Chemistry & Biochemistry, Stephenson Life Science Research Center, University of Oklahoma, Norman, Oklahoma 73019, United States.
O'Keefe BR; Natural Products Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, and Molecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, United States.
Doench JG; Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, United States.
Cichewicz RH; Natural Products Discovery Group, Institute for Natural Products Applications and Research Technologies, Department of Chemistry & Biochemistry, Stephenson Life Science Research Center, University of Oklahoma, Norman, Oklahoma 73019, United States.

J Nat Prod ; 83(10): 3080-3092, 2020 10 23.

Article en En | MEDLINE | ID: mdl-33021790

Asunto(s)

Antineoplásicos Fitogénicos/farmacología; Neoplasias de la Mama/tratamiento farmacológico; Sistemas CRISPR-Cas; Técnicas de Inactivación de Genes/métodos; Células Madre Neoplásicas/efectos de los fármacos; Neoplasias de la Mama Triple Negativas/tratamiento farmacológico; 17-Hidroxiesteroide Deshidrogenasas/efectos de los fármacos; 17-Hidroxiesteroide Deshidrogenasas/genética; Aldehído Oxidorreductasas/efectos de los fármacos; Aldehído Oxidorreductasas/genética; Línea Celular Tumoral; Femenino; Humanos; Estructura Molecular; PPAR gamma/agonistas; ARN Interferente Pequeño/farmacología

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Texto completo: 1 Colección: 01-internacional Asunto principal: Células Madre Neoplásicas / Neoplasias de la Mama / Técnicas de Inactivación de Genes / Neoplasias de la Mama Triple Negativas / Sistemas CRISPR-Cas / Antineoplásicos Fitogénicos Tipo de estudio: Clinical_trials Límite: Female / Humans Idioma: En Revista: J Nat Prod Año: 2020 Tipo del documento: Article

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